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Other side effects of estrogens include an increased risk of blood clots, cardiovascular disease, and, when combined with most progestogens, breast cancer. [1] In men, estrogens can cause breast development, feminization, infertility, low testosterone levels, and sexual dysfunction among others.
Side effects of estradiol in women include breast tenderness, breast enlargement, headache, fluid retention, and nausea among others. [ 11 ] [ 20 ] Men and children who are exposed to estradiol may develop symptoms of feminization , such as breast development and a feminine pattern of fat distribution , and men may also experience low ...
Side effects of HDE specific to men may include gynecomastia (breast development), feminization and demasculinization in general (e.g., reduced body hair, decreased muscle mass and strength, feminine changes in fat mass and distribution, and reduced penile and testicular size), and sexual dysfunction (e.g., reduced libido and erectile dysfunction).
Experts call vaginal estrogen "the holy grail" for its effectiveness in improving vulvar or vaginal itching and burning, painful sex and recurring UTIs.
The risk of VTE with estradiol/nomegestrol acetate birth control pills is under study. [11] Incidence of irregular vaginal bleeding may be higher with estradiol-containing birth control pills in relation to the fact that estradiol is a weaker estrogen than ethinylestradiol in the endometrium. [3]
Examples of such side effects include breast tenderness and enlargement, nausea, bloating, edema, headache, and melasma. [ 15 ] [ 62 ] High-dose estrogen therapy with estradiol valerate injections may also cause an increased risk of thromboembolism , changes in blood lipid profile , increased insulin resistance , and increased levels of prolactin .
Why Spanish Fly Pills Aren’t Worth It Spanish fly isn’t just ineffective as an aphrodisiac — it’s also dangerous. So keep Spanish fly and other herbal aphrodisiacs at arm’s length.
The World Health Organization (WHO) does not recommend the use of combined oral contraceptive pills in women with breast cancer. [41] [97] Since combined oral contraceptive pills contain both estrogen and progestin, they are not recommended to be used in those with hormonally-sensitive cancers, including some types of breast cancer.