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Transferrin receptor protein 1 (TfR1), also known as Cluster of Differentiation 71 (CD71), is a protein that in humans is encoded by the TFRC gene. [ 5 ] [ 6 ] TfR1 is required for iron import from transferrin into cells by endocytosis .
TfR2 binds to transferrin with a 25-30 fold lower affinity than TfR1. [3] [4] Although TfR1 mediated iron uptake is the major pathway for iron acquisition by most cells and especially developing erythrocytes, several studies have indicated that the uptake mechanism varies depending upon the cell type. It is also reported that Tf uptake exists ...
Each monomer consists of three domains: the protease, the helical, and the apical domains. The shape of a transferrin receptor resembles a butterfly based on the intersection of three clearly shaped domains. [18] Two main transferrin receptors found in humans denoted as transferrin receptor 1 (TfR1) and transferrin receptor 2 (TfR2).
The transferrin receptor mRNA is rapidly degraded without the IRE-BP attached to it. The cell stops producing transferrin receptors. When the cell has obtained more iron than it can bind up with ferritin or heme molecules, more and more iron will bind to the IRE-BPs. That will stop transferrin receptor production.
Conventional iron uptake pathways, such as those using the transferrin receptor 1 (TfR1), often prove insufficient to meet these elevated iron demands in cancer cells. As a result, various cytokines and growth factors trigger the upregulation of CD44, a surface molecule capable of internalizing iron bound to the hyaluronan complex. This ...
Transferrin receptor (Transferrin receptor protein 1 - TfR1), mediates cellular uptake of iron. Ubiquitously expressed on dividing, normal (haematological precursors) and malignant cells. Currently investigated as a target for an antibody ("probody") drug conjugate from Cytomx / Abbvie to treat various cancers. CD72
They are found in the cytoplasmic tails of non-catalytic tyrosine-phosphorylated receptors [7] such as the CD3 and ζ-chains of the T cell receptor complex, the CD79-alpha and -beta chains of the B cell receptor complex, and certain Fc receptors. [1] [7] The tyrosine residues within these motifs become phosphorylated by Src family kinases ...
Transferrin receptor 2 (TfR2) is a protein that in humans is encoded by the TFR2 gene. [ 5 ] [ 6 ] This protein is involved in the uptake of transferrin -bound iron into cells by endocytosis , although its role is minor compared to transferrin receptor 1 .