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The mecA gene, which confers resistance to a number of antibiotics, is always present in MRSA and usually absent in MSSA; however, in some instances, the mecA gene is present in MSSA but is not expressed. Polymerase chain reaction (PCR) testing is the most precise method for identifying MRSA strains. Specialized culture media have been ...
SCCmec, or staphylococcal cassette chromosome mec, is a mobile genetic element of Staphylococcus bacterial species. This genetic sequence includes the mecA gene coding for resistance to the antibiotic methicillin and is the only known way for Staphylococcus strains to spread the gene in the wild by horizontal gene transfer. [1]
SCCmec is a family of mobile genetic elements, which is a major driving force of S. aureus evolution. [99] Resistance is conferred by the mecA gene, which codes for an altered penicillin-binding protein (PBP2a or PBP2') that has a lower affinity for binding β-lactams (penicillins, cephalosporins, and carbapenems). This allows for resistance to ...
Meca or MECA may refer to: Biology. mecA, responsible for methicillin resistance in MRSA; Meca, a snout moth genus in the subfamily Pyralinae; Places Meca ...
Resistance to methicillin is conferred by activation of a new bacterial penicillin binding protein (PBP) mecA gene. This encodes protein PBP2a. This encodes protein PBP2a. PBP2a works in a similar manner to other PBPs, but it binds β-lactams with very low affinity, meaning they do not compete efficiently with the natural substrate of the ...
Genetic testing, such as via polymerase chain reaction (PCR), DNA microarray, and loop-mediated isothermal amplification, may be used to detect whether bacteria possess genes which confer antibiotic resistance. [9] [23] An example is the use of PCR to detect the mecA gene for beta-lactam resistant Staphylococcus aureus. [9]
History books can only cover so much, and most of us haven’t cracked one open since we were in college. But if you want to learn about some fascinating moments from the past, accompanied by ...
The mecA gene is carried by a mobile genetic element called the staphylococcal cassette chromosome mec (SCCmec) which is thought to promote spread between different species. [58] The presence of the mecA gene, expression of PBP2a, and methicillin resistance has been reported in S. schleiferi isolates. [13]