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Dabie bandavirus, also called SFTS virus, is a tick-borne virus in the genus Bandavirus in the family Phenuiviridae, order Bunyavirales. [2] The clinical condition it caused is known as severe fever with thrombocytopenia syndrome (SFTS). [ 2 ]
SFTS is an emerging infectious disease causing fever, vomiting, diarrhea, loss of consciousness and heamorrhage. [1]SFTS has fatality rates ranging from 12% to as high as 30% in some areas due to multiple organ failure, thrombocytopenia (low platelet count), leucopenia (low white blood cell count), and elevated liver enzyme levels.
Phlebovirus is one of twenty genera of the family Phenuiviridae in the order Bunyavirales. The genus contains 66 species. [ 1 ] It derives its name from Phlebotominae , the vectors of member species Naples phlebovirus , which is said to be ultimately from the Greek phlebos , meaning "vein". [ 2 ]
Phenuiviridae is a family of negative-strand RNA viruses in the order Bunyavirales. [1] Ruminants, camels, humans, and mosquitoes serve as natural hosts.Until 2011, member genus Phlebovirus was the only genus of the family with viruses causing disease in humans (e.g. Rift Valley fever virus) [2] [scientific citation needed] except Dabie bandavirus.
SFTS may refer to: San Francisco Theological Seminary , a graduate school affiliated with Presbyterian Church (U.S.A.) located in San Anselmo, California Severe fever with thrombocytopenia syndrome , an infectious disease caused by SFTS virus
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Phlebotomus species are also vectors for bartonellosis, verruga peruana, and pappataci fever, an arboviral disease caused by sandfly fever viruses such as the Naples and Sicilian strains of the genus Phlebovirus (family Bunyaviridae), which also includes the closely related Toscana virus.
As a Phlebovirus, it has an ambisense genome. Its L and M segments are negative-sense, but its S segment is ambisense. [5] These three genome segments code for six major proteins: L protein (viral polymerase), the two glycoproteins G(N) and G(C), the nucleocapsid N protein, and the nonstructural NSs and NSm proteins. [6]