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Mifepristone, and also known by its developmental code name RU-486, is a drug typically used in combination with misoprostol to bring about a medical abortion during pregnancy. [8] This combination is 97% effective [9] during the first 63 days (9 weeks) of pregnancy, yet effective in the second trimester as well.
The mifepristone-misoprostol combination is, by far, the most recommended drug regimen for medical abortions, but other drug combinations are available. Misoprostol alone, without mifepristone, may be used in some circumstances for medical abortion, and has even been demonstrated to be successful in the second trimester. [37]
The most common early first trimester medical abortion regimens use mifepristone in combination with misoprostol (or sometimes another prostaglandin analog, gemeprost) up to 10 weeks (70 days) gestational age, [64] [65] methotrexate in combination with a prostaglandin analog up to 7 weeks gestation, or a prostaglandin analog alone. [19]
The U.S. Supreme Court will take up a case Tuesday that could impact how women get access to mifepristone, one of the two pills used in the most common type of abortion in the nation.
The Supreme Court just tossed out a case that challenged access to a widely used abortion drug. Here's what that means and what's next.
Is mifepristone available? Here's what to know about the Supreme Court ruling on access to the abortion medication.
Misoprostol is used for the prevention of NSAID-induced gastric ulcers.It acts upon gastric parietal cells, inhibiting the secretion of gastric acid by G-protein coupled receptor-mediated inhibition of adenylate cyclase, which leads to decreased intracellular cyclic AMP levels and decreased proton pump activity at the apical surface of the parietal cell.
The nation’s highest court will weigh in on a challenge to the FDA’s approval of the drug
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