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  2. FDA approves new pain medication as an alternative to opioids ...

    www.aol.com/news/fda-approves-pain-medication...

    The drug, suzetrigine, received the FDA's official stamp of approval Thursday to be sold as a 50-milligram prescription pill taken every 12 hours, according to a press release.

  3. Sentinel cell - Wikipedia

    en.wikipedia.org/wiki/Sentinel_cell

    Sentinel cells refer to cells in the body's first line of defense, which embed themselves in tissues such as skin. [1] Sentinel cells represent diverse array of cell types with the capability to monitor the presence of exogenous or potentially harmful particles and play a crucial role in recognizing and sampling signs of infection or abnormal cellular activity and/or death.

  4. Targeted covalent inhibitors - Wikipedia

    en.wikipedia.org/wiki/Targeted_covalent_inhibitors

    Targeted covalent inhibitors (TCIs) or Targeted covalent drugs are rationally designed inhibitors that bind and then bond to their target proteins.These inhibitors possess a bond-forming functional group of low chemical reactivity that, following binding to the target protein, is positioned to react rapidly with a proximate nucleophilic residue at the target site to form a bond.

  5. Fentanyl - Wikipedia

    en.wikipedia.org/wiki/Fentanyl

    The intravenous dose causing 50% of opioid-naive experimental subjects to die (LD 50) is "3 mg/kg in rats, 1 mg/kg in cats, 14 mg/kg in dogs, and 0.03 mg/kg in monkeys." [ 98 ] The LD 50 in mice has been given as 6.9 mg/kg by intravenous administration, 17.5 mg/kg intraperitoneally, 27.8 mg/kg by oral administration. [ 99 ]

  6. FDA approves opioid-free pain medication with 'no sign of ...

    www.aol.com/news/fda-approves-opioid-free-pain...

    A new opioid-free pain medication was approved by the U.S. Food and Drug Administration (FDA) on Thursday, marking a non-addictive alternative for patients. Journavx (suzetrigine), made by Vertex ...

  7. FDA approves painkiller designed to eliminate the risk of ...

    www.aol.com/news/fda-approves-painkiller...

    The new drug will carry a list price of $15.50 per pill, making it many times more expensive than comparable opioids, which are often available as generics for $1 or less.

  8. IC50 - Wikipedia

    en.wikipedia.org/wiki/IC50

    IC 50 values are typically expressed as molar concentration. IC 50 is commonly used as a measure of antagonist drug potency in pharmacological research. IC 50 is comparable to other measures of potency, such as EC 50 for excitatory drugs. EC 50 represents the dose or plasma concentration required for obtaining 50% of a maximum effect in vivo. [1]

  9. FDA approves new type of non-opioid pain medication, 1st of ...

    www.aol.com/news/fda-approves-type-non-opioid...

    The U.S. Food and Drug Administration (FDA) on Thursday approved a new type of prescription pain medication for adults to treat moderate to severe acute pain. The drug, called Journavx ...

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