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Tooth development begins at week 6 in utero, in the oral epithelium. The process is divided into three stages: Initiation; Morphogenesis and; Histogenesis [2]; At the end of week 7 i.u., localised proliferations of cells in the dental laminae form round and oval swellings known as tooth buds, which will eventually develop into mesenchymal cells and surround the enamel organ.
The tooth bud (sometimes called the tooth germ) is an aggregation of cells that eventually forms a tooth and is organized into three parts: the enamel organ, the dental papilla and the dental follicle. [3] The enamel organ is composed of the outer enamel epithelium, inner enamel epithelium, stellate reticulum and stratum intermedium. [3]
Tonofilaments separate the developing enamel from the enamel organ. Gap junctions synchronize cell activation. The body of the cell between the processes first deposits enamel, which will become the periphery of the enamel prisms, then the Tomes's process will infill the main body of the enamel prism.
It is organized into three parts: the enamel organ, the dental papilla and the dental follicle. [27] The enamel organ is composed of the outer enamel epithelium, inner enamel epithelium, stellate reticulum and stratum intermedium. [27] These cells give rise to ameloblasts, which produce enamel and the reduced enamel epithelium.
The Hertwig epithelial root sheath (HERS) or epithelial root sheath is a proliferation of epithelial cells located at the cervical loop of the enamel organ in a developing tooth. Hertwig epithelial root sheath initiates the formation of dentin in the root of a tooth by causing the differentiation of odontoblasts from the dental papilla.
The enamel organ → purely the epithelial component; The tissues which have been derived from each of the three components are: The dental follicle → will develop to become the periodontal ligament, the cementum and the alveolar bone; The dental papilla → will develop to become the dental pulp and the dentine; The enamel organ → will ...
In the tooth bud, regions where enamel formation is completed, the enamel organ gives rise to Hertwig's epithelial root sheath, composed of two epithelial layers derived from the external and internal epithelia. The sheath is irregularly fragmented in time and space as it promotes cementum deposition on the newly formed dentin.
After the formation of enamel matrix, mineralisation of enamel takes place which is known as maturation. During this stage, the ameloblasts are slightly reduced in length. The stratum intermedium cells lose their cuboidal shape and assumed to be as spindle shape. During this stage, ameloblasts also exhibit microvilli at their distal extremities.