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When cannabis is smoked, blood levels of THC peak rapidly after a few minutes and then decline, although the psychotropic effects persist for longer. Edible forms of cannabis often contain tens to hundreds of milligrams of THC, much more than the 32 mg of a typical cannabis cigarette.
Such effects may include analgesia, decreased inflammation, decreased spasticity, and anti-seizure effects. [26] Cannabis edibles with CBD can decrease symptoms of psychosis and anxiety. [25] Edible oils, tinctures, pills, and gummies have been prescribed to people with cancer to potentially improve poor appetite, pain, or weight loss. [27]
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The time to onset of effects depends strongly on stomach content, but is usually 1 to 2 hours, and may continue for a considerable length of time, whereas the effects of smoking or vaporizing cannabis are almost immediate, lasting a shorter length of time. [10] All of the active constituents enter the body when cannabis is consumed orally.
Because marijuana stays in your system long past the window of cognitive impairment, the potential for false arrests is an increasing concern in states where cannabis is legal.
Edibles, which include baked goods, candies and beverages, are increasingly popular, said lead research author Dr. Nathan Stall, a geriatrician and clinician scientist at Sinai Health in Ontario.
There is a slight increase in dose proportionality in terms of peak and area-under-the-curve levels of THC with increasing oral doses over a range of 2.5 to 10 mg. [22] A high-fat meal delays time to peak concentrations of oral THC by 4 hours on average and increases area-under-the-curve exposure by 2.9-fold, but peak concentrations are not ...
The metabolism of THC into 11-OH-THC plays a part in the heightened psychoactive effects of edible cannabis. [ 65 ] Next, 11-OH-THC is metabolized in the liver into 11-COOH-THC, which is the second metabolic product of THC.