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Lassa virus life cycle. Figure by Fehling et al., 2012 [13] The life cycle of Lassa mammarenavirus is similar to the Old World arenaviruses. Lassa mammarenavirus enters the cell by the receptor-mediated endocytosis. Which endocytotic pathway is used is not known yet, but at least the cellular entry is sensitive to cholesterol depletion.
An arenavirus is a bi- or trisegmented ambisense RNA virus that is a member of the family Arenaviridae. [1] [2] These viruses infect rodents and occasionally humans.A class of novel, highly divergent arenaviruses, properly known as reptarenaviruses, have also been discovered which infect snakes to produce inclusion body disease, mostly in boa constrictors.
Viral replication is the formation of biological viruses during the infection process in the target host cells. Viruses must first get into the cell before viral replication can occur. Through the generation of abundant copies of its genome and packaging these copies, the virus continues infecting new hosts. Replication between viruses is ...
Lassa fever, also known as Lassa hemorrhagic fever, is a type of viral hemorrhagic fever caused by the Lassa virus. [1] Many of those infected by the virus do not develop symptoms . [ 1 ] When symptoms occur they typically include fever , weakness, headaches, vomiting , and muscle pains . [ 1 ]
Description from Scheme of Influenza A virus replication (NCBI): "A virion attaches to the host cell membrane via HA and enters the cytoplasm by receptor-mediated endocytosis (STEP 1), thereby forming an endosome. A cellular trypsin-like enzyme cleaves HA into products HA1 and HA2 (not shown).
Bunyavirales is an order of segmented negative-strand RNA viruses with mainly tripartite genomes. Member viruses infect arthropods, plants, protozoans, and vertebrates. [2] It is the only order in the class Ellioviricetes. [1]
English: Lassa Fever Outbreak Distribution Map 2014. Countries reporting endemic disease and substantioal outbreaks of Lassa Fever in blue. Countries reporting few cases, periodic isolation of virus, or serological evidence of infection in green. Countries with unknown status in grey.