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Medroxyprogesterone acetate (MPA), also known as depot medroxyprogesterone acetate (DMPA) in injectable form and sold under the brand name Depo-Provera among others, is a hormonal medication of the progestin type. [10] [4] It is used as a method of birth control and as a part of menopausal hormone therapy.
In the past, medrogestone was used in the treatment of endometrial cancer and in some regimens for breast cancer, and, in men, for benign prostatic hyperplasia. It still finds use in the treatment of amenorrhea [ 14 ] and as the progestin component in certain forms of menopausal hormone therapy .
Progestogens have been found to maximally suppress circulating testosterone levels in men by up to 70 to 80% at sufficiently high doses. [ 219 ] [ 220 ] This is notably less than that achieved by GnRH analogues , which can effectively abolish gonadal production of testosterone and suppress circulating testosterone levels by as much as 95%. [ 221 ]
Medroxyprogesterone, also known as 6α-methyl-17α-hydroxyprogesterone or as 6α-methyl-17α-hydroxypregn-4-en-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone. [ 2 ] [ 3 ] It is specifically a derivative of 17α-hydroxyprogesterone with a methyl group at the C6α position.
In 1981, in an experiment by Pierre Gagné, 48 males with long-standing histories of sexually deviant behaviour were given medroxyprogesterone acetate for as long as 12 months. Forty of those subjects were recorded as having diminished desires for deviant sexual behaviour, as well as less frequent sexual fantasies and greater control over ...
Medroxyprogesterone acetate [c] Provera [b] Progestin: Oral: 5–10mg/day Depo-Provera [b] Progestin: IM: 150mg every 3 months Depo-SubQ Provera 104: Progestin: SC: 104mg every 3 months Lynestrenol [c] Orgametril [b] Progestin: Oral: 5–10mg/day Finasteride [d] Propecia [b] 5αR inhibitor: Oral: 1mg/day Dutasteride [d] Avodart: 5αR inhibitor ...
Progestogens that have been studied for potential use as POICs but were never marketed as such include the progesterone derivatives algestone acetophenide (dihydroxyprogesterone acetophenide) (100 mg/month), chlormadinone acetate (250 mg/3 months), hydroxyprogesterone caproate (250–500 mg/month), gestonorone caproate (2.5–200 mg/1–2 ...
Use of combined oral contraceptive pills, however, varies widely by country, [18] age, education, and marital status. For example, one third of women aged 16–49 in the United Kingdom use either the combined pill or progestogen-only pill (POP), [ 19 ] [ 20 ] compared with less than 3% of women in Japan (as of 1950–2014).