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  2. Your ED Pill Guide: Everything You Need to Know Before ... - AOL

    www.aol.com/ed-pill-guide-everything-know...

    Sildenafil (Viagra), tadalafil (Cialis) and vardenafil (Levitra) typically start working within 30 to 60 minutes, while avanafil (Stendra) works within 15 to 30 minutes. As with most prescription ...

  3. How to Take Viagra for Best Results - AOL

    www.aol.com/viagra-best-results-105700318.html

    Viagra works best when it’s taken at least 30 to 60 minutes before intimacy (and no more than four hours before). Eating food that’s high in fat can slow absorption and make Viagra work ...

  4. Sildenafil - Wikipedia

    en.wikipedia.org/wiki/Sildenafil

    This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil. Thus, the metabolite is responsible for about 20% of sildenafil's action. Sildenafil is excreted as metabolites predominantly in the feces (about 80% of administered oral dose) and to a lesser extent in the urine (around 13% of the administered oral dose).

  5. Things You Probably Don't Know About Viagra (Like What ... - AOL

    www.aol.com/things-probably-dont-know-viagra...

    How Long Does Viagra Take to Work? Viagra usually starts working 30 to 60 minutes after taking it. But simply swallowing the little blue pill won’t automatically make you hard — you still have ...

  6. PDE5 inhibitor - Wikipedia

    en.wikipedia.org/wiki/PDE5_inhibitor

    Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.

  7. Is Sildenafil Safe for This Common Male Problem? - AOL

    www.aol.com/lifestyle/sildenafil-safe-common...

    Sildenafil is most effective when taken at least 30 minutes to one hour before intimacy. For most people, it can provide ED relief for around four hours before it begins to decrease in the body.

  8. 5 Must-Know Tips Before Taking Sildenafil 100mg - AOL

    www.aol.com/5-must-know-tips-taking-105700758.html

    For example, in clinical trials of sildenafil, 28 percent of men reported headache (by far the most common side effect) at a dosage of 100mg, compared to just 16 percent of men who used 25mg and ...

  9. What Does Viagra Actually Do to Your "Intimate" Experience? - AOL

    www.aol.com/does-viagra-actually-intimate...

    For example, a small study of 20 people that looked into Viagra’s effect on refractory time found that a standard 100mg dose of sildenafil citrate reduced the average male post-intimacy recovery ...

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