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2. Complement system - Wikipedia

   en.wikipedia.org/wiki/Complement_system

   The complement system, also known as complement cascade, is a part of the humoral, innate immune system and enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. [1]

3. C1 complex - Wikipedia

   en.wikipedia.org/wiki/C1_complex

   Activation of the C1 complex initiates the classical complement pathway. This occurs when C1q binds to antigen-antibody complexes. The antibodies IgM or certain subclasses of IgG complexed with antigens are able to initiate the complement system: a single pentameric IgM can initiate the pathway, while several monomeric IgG molecules are needed. [3]

4. Humoral immunity - Wikipedia

   en.wikipedia.org/wiki/Humoral_immunity

   The study of the molecular and cellular components that form the immune system, including their function and interaction, is the central science of immunology. The immune system is divided into a more primitive innate immune system and an acquired or adaptive immune system of vertebrates , each of which contain both humoral and cellular immune ...

5. Lectin pathway - Wikipedia

   en.wikipedia.org/wiki/Lectin_pathway

   Structure of mannose in its α-D mannopyranose form. Mannan is a polymer of mannose.. The lectin pathway or MBL pathway is a type of cascade reaction in the complement system, similar in structure to the classical complement pathway, [1] in that, after activation, it proceeds through the action of C4 and C2 to produce activated complement proteins further down the cascade.

6. Alternative complement pathway - Wikipedia

   en.wikipedia.org/wiki/Alternative_complement_pathway

   The alternative pathway is a type of cascade reaction of the complement system and is a component of the innate immune system, a natural defense against infections. The alternative pathway is one of three complement pathways that opsonize and kill pathogens. The pathway is triggered when the C3b protein directly binds a microbe. It can also be ...

7. Classical complement pathway - Wikipedia

   en.wikipedia.org/wiki/Classical_complement_pathway

   Classical complement activation has also been shown to combat Methicillin-resistant Staphylococcus aureus. [10] Certain variants of the IgM antibody were found to bind the Methicillin-resistant Staphylococcus aureus these IgM were found to be critical in complement activation through the classical pathway and subsequent destruction of the bacteria.

8. Complement - Wikipedia

   en.wikipedia.org/wiki/Complement

   Complement system (immunology), a cascade of proteins in the blood that form part of innate immunity; Complementary DNA, DNA reverse transcribed from a mature mRNA template; Complementarity (molecular biology), a property whereby double stranded nucleic acids pair with each other

9. C5-convertase - Wikipedia

   en.wikipedia.org/wiki/C5-convertase

   The complement component C5 can be also activated by fluid phase C5 convertase. C5 is activated by CVFBb in the presence of complement component C6 and the C5b6 complex is formed. However, when C6 is added after C5 has been converted to C5b, the C5b6 complex fails to form. Therefore, the activation of C5 results in a transient binding site for C6.