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Uridine 5'-diphospho-glucuronosyltransferase (UDP-glucuronosyltransferase, UGT) is a microsomal glycosyltransferase (EC 2.4.1.17) that catalyzes the transfer of the glucuronic acid component of UDP-glucuronic acid to a small hydrophobic molecule. This is a glucuronidation reaction. [2] [3] Alternative names: glucuronyltransferase; UDP ...
UDP-glucuronosyltransferase 1-1 also known as UGT-1A is an enzyme that in humans is encoded by the UGT1A1 gene. [5] [6]UGT-1A is a uridine diphosphate glucuronosyltransferase (UDP-glucuronosyltransferase, UDPGT), an enzyme of the glucuronidation pathway that transforms small lipophilic (fat-soluble) molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable ...
UDP glucuronosyltransferase 1 family, polypeptide A7 is a protein that in humans is encoded by the UGT1A7 gene. [ 5 ] This gene encodes a UDP-glucuronosyltransferase , an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids , bilirubin , hormones , and drugs, into water-soluble, excretable metabolites.
UGT2B7 (UDP-Glucuronosyltransferase-2B7) is a phase II metabolism isoenzyme found to be active in the liver, kidneys, epithelial cells of the lower gastrointestinal tract and also has been reported in the brain. In humans, UDP-Glucuronosyltransferase-2B7 is encoded by the UGT2B7 gene. [5] [6]
n/a Ensembl n/a n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a Wikidata View/Edit Human UDP glucuronosyltransferase 1 family, polypeptide A cluster (UGT1A) is a human gene locus that includes several UDP glucuronosyltransferases. The UGT1A locus includes thirteen unique alternate first exons followed by four common exons. Four of ...
Glucuronidation consists of transfer of the glucuronic acid component of uridine diphosphate glucuronic acid to a substrate by any of several types of UDP-glucuronosyltransferase. UDP-glucuronic acid (glucuronic acid linked via a glycosidic bond to uridine diphosphate ) is an intermediate in the process and is formed in the liver .
UDP-glucuronosyltransferase 1-4 is an enzyme that in humans is encoded by the UGT1A4 gene. [ 5 ] [ 6 ] [ 7 ] This gene encodes a UDP-glucuronosyltransferase , an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids , bilirubin , hormones, and drugs, into water-soluble, excretable metabolites .
UDP glucuronosyltransferase 2 family, polypeptide B4, also known as UGT2B4, is an enzyme that in humans is encoded by the UGT2B4 gene. [5] [6] [7] Function.