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Fundic gland polyposis is a medical syndrome where the fundus and the body of the stomach develop many fundic gland polyps. The condition has been described both in patients with familial adenomatous polyposis (FAP) and attenuated variants (AFAP), and in patients in whom it occurs sporadically.
Fundic gland polyps are found in 0.8 to 1.9% of patients who undergo esophagogastroduodenoscopy, and are more common in middle-aged women. [2] The risk of malignancy is very low or none, when sporadic. [3] Fundic gland polyposis is a medical syndrome with multiple fundic gland polyps.
A polyp is an abnormal growth of tissue projecting from a mucous membrane. If it is attached to the surface by a narrow elongated stalk, it is said to be pedunculated; if it is attached without a stalk, it is said to be sessile. Polyps are commonly found in the colon, stomach, nose, ear, sinus(es), urinary bladder, and uterus.
Fundic gland polyposis is a medical syndrome where the fundus and the body of the stomach develop many fundic gland polyps. Pernicious anemia is caused when damaged parietal cells fail to produce the intrinsic factor necessary for the absorption of vitamin B12. This is the most common cause of vitamin B12 deficiency.
Reactive gastropathy is morphologically distinct entity [3] [4] that can be separated from gastritis, which by definition has a significant inflammatory component.. As a reactive gastropathy may mimic a (true) gastritis symptomatically and visually in an endoscopic examination, it may incorrectly be referred to as a gastritis.
Autoimmune conditions can often be managed with various treatments; however, little is known about how or if these treatments effect achlorhydria. [5] Thyroid hormones can contribute to changes in the level of hydrochloric acid in the stomach. Hypothyroidism is associated with a greater risk of developing achlorhydria. [5]
Long-term use of PPIs is associated with the development of benign polyps from fundic glands (which is distinct from fundic gland polyposis); these polyps do not cause cancer and resolve when PPIs are discontinued. [33] There is concern that use of PPIs may mask gastric cancers or other serious gastric problems. [33]
Vonoprazan, sold under the brand name Voquezna among others, is a first-in-class potassium-competitive acid blocker medication. [2] [1] Vonoprazan is used in form of the fumarate for the treatment of gastroduodenal ulcer (including some drug-induced peptic ulcers) and reflux esophagitis, and can be combined with antibiotics for the eradication of Helicobacter pylori.