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Central nervous system fatigue, or central fatigue, is a form of fatigue that is associated with changes in the synaptic concentration of neurotransmitters within the central nervous system (CNS; including the brain and spinal cord) which affects exercise performance and muscle function and cannot be explained by peripheral factors that affect muscle function.
[20]: 564 The classification of ME/CFS as a neurological disease is based on symptoms, which indicate a central role of the nervous system. [21] Alternatively, based on abnormalities in immune cells, ME/CFS is sometimes labelled a neuroimmune condition. [22]
Neurasthenia (from the Ancient Greek νεῦρον neuron "nerve" and ἀσθενής asthenés "weak") is a term that was first used as early as 1829 [6] for a mechanical weakness of the nerves. [clarification needed] It became a major diagnosis in North America during the late nineteenth and early twentieth centuries after neurologist George ...
Central nervous system diseases or central nervous system disorders are a group of neurological disorders that affect the structure or function of the brain or spinal cord, which collectively form the central nervous system (CNS). [1][2][3] These disorders may be caused by such things as infection, injury, blood clots, age related degeneration ...
Management of ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome) focuses on symptoms management, as no treatments that address the root cause of the illness are available. [1]: 29 Pacing, or regulating one's activities to avoid triggering worse symptoms, is the most common management strategy for post-exertional malaise.
Multiple sclerosis (MS) is an autoimmune disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged. [ 3 ] Being a demyelinating disease, MS disrupts the ability of parts of the nervous system to transmit signals, resulting in a range of signs and symptoms, including physical, mental, and sometimes ...
Idiopathic hypersomnia(IH) is a neurological disorder which is characterized primarily by excessive sleep and excessive daytime sleepiness (EDS). [ 1 ] Idiopathic hypersomnia was first described by Bedrich Roth in 1976, and it can be divided into two forms: polysymptomatic and monosymptomatic. [ 2 ][ 3 ] The condition typically becomes evident ...
The central component of fatigue is triggered by an increase of the level of serotonin in the central nervous system. [133] During motor activity, serotonin released in synapses that contact motor neurons promotes muscle contraction. [134] During high level of motor activity, the amount of serotonin released increases and a spillover occurs.