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General anesthesia is usually considered safe; however, there are reported cases of patients with distortion of taste and/or smell due to local anesthetics, stroke, nerve damage, or as a side effect of general anesthesia. [46] [47] At the end of surgery, administration of anaesthetic agents is discontinued.
A lower MAC value represents a more potent volatile anesthetic. Other uses of MAC include MAC-BAR (1.7–2.0 MAC), which is the concentration required to block autonomic reflexes to nociceptive stimuli, and MAC-awake (0.3–0.5 MAC), the concentration required to block voluntary reflexes and control perceptive awareness.
Sedoanalgesia is the practice of combining sedation with local anesthesia, usually in the case of surgery.In medical studies, administering sedoanalgesia has been shown to be cost- and time-effective when compared to general or regional anesthesia, and it can reduce the amount of nursing staff, anesthetists, and equipment required for a given procedure.
Balanced anesthesia can make patients calm by using drugs such as: medetomidine, diazepam or midazolam, and acepromazine. [18] Keeping patients calm prior to surgery can avoid the unpredictable consequences of stress, such as tachypnea, hypertension and tachycardia which may be harmful to the anesthetized patients. [18]
Full wakefulness and general anesthesia are the two extremes of the spectrum. Conscious sedation and monitored anesthesia care (MAC) refer to an awareness somewhere in the middle of the spectrum, depending on the degree to which a patient is sedated. Monitored anesthesia care involves titration of local anesthesia along with sedation and ...
The Meyer-Overton correlation for anaesthetics. A nonspecific mechanism of general anaesthetic action was first proposed by Emil Harless and Ernst von Bibra in 1847. [9] They suggested that general anaesthetics may act by dissolving in the fatty fraction of brain cells and removing fatty constituents from them, thus changing activity of brain cells and inducing anaesthesia.
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The purpose of anesthesia can be distilled down to three basic goals or endpoints: [2]: 236 hypnosis (a temporary loss of consciousness and with it a loss of memory.In a pharmacological context, the word hypnosis usually has this technical meaning, in contrast to its more familiar lay or psychological meaning of an altered state of consciousness not necessarily caused by drugs—see hypnosis).