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5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme (EC 2.7.11.31) that plays a role in cellular energy homeostasis, largely to activate glucose and fatty acid uptake and oxidation when cellular energy is low.
5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) is an intermediate in the generation of inosine monophosphate. AICAR is an analog of adenosine monophosphate (AMP) that is capable of stimulating AMP-dependent protein kinase (AMPK) activity. The drug has also been shown as a potential treatment for diabetes by increasing the metabolic ...
5563 108079 Ensembl ENSG00000162409 ENSMUSG00000028518 UniProt P54646 Q8BRK8 RefSeq (mRNA) NM_006252 NM_178143 NM_001356568 RefSeq (protein) NP_006243 NP_835279 NP_001343497 Location (UCSC) Chr 1: 56.65 – 56.72 Mb Chr 4: 104.89 – 104.97 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse 5'-AMP-activated protein kinase catalytic subunit alpha-2 is an enzyme that in humans is encoded ...
5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene. [5] [6] The protein encoded by this gene belongs to the serine/threonine protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase . AMPK is a cellular energy sensor conserved in all ...
This pioneering concept classifies patients according to their level of risk and tailors their treatment protocol accordingly. When Dr. Priscilla White joined Joslin's practice in 1924, only 56 percent of babies born to diabetic mothers survived; 50 years later when she retired, that rate had jumped to more than 90 percent.
The root is used in decoctions against fevers, diabetes, diseases of urinary system and constipation. The leaves have laxative properties. The dried flowers and flower buds are used as a substitute for tea in case of diabetes patients. The powdered seed is also applied to the eye, in case of chronic purulent conjunctivitis. [citation needed]
The American Diabetes Association (ADA) is a United States-based nonprofit that seeks to educate the public about diabetes and to help those affected by it through funding research to manage, cure and prevent diabetes, including type 1 diabetes, type 2 diabetes, gestational diabetes, and pre-diabetes. It is a network of 565,000 volunteers which ...
Various hereditary conditions may feature diabetes, for example myotonic dystrophy and Friedreich's ataxia. Wolfram's syndrome is an autosomal recessive neurodegenerative disorder that first becomes evident in childhood. It consists of diabetes insipidus, diabetes mellitus, optic atrophy, and deafness, hence the acronym DIDMOAD. [20]