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Aspirin/paracetamol/caffeine is a combination drug for the treatment of pain, especially tension headache and migraine. [1] It contains aspirin , a non-steroidal anti-inflammatory drug ; paracetamol (acetaminophen), an analgesic ; and caffeine , a stimulant .
The WHO guidelines recommend prompt oral administration of drugs ("by the mouth") when pain occurs, starting, if the patient is not in severe pain, with non-opioid drugs such as paracetamol (acetaminophen) or aspirin, [1] with or without "adjuvants" such as non-steroidal anti-inflammatory drugs (NSAIDs) including COX-2 inhibitors.
An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
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Paracetamol, [a] or acetaminophen, [b] is a non-opioid analgesic and antipyretic agent used to treat fever and mild to moderate pain. [13] [14] [15] It is a widely available over-the-counter drug sold under various brand names, including Tylenol and Panadol. Paracetamol relieves pain in both acute mild migraine and episodic tension headache.
Aspirin helps prevent blood clots from forming, which is the leading cause of heart attack and stroke, but the drug also carries a risk of bleeding. That risk can outweigh aspirin’s benefits in ...
The Tylenol murderer was never found, (though later James Lewis was a prime suspect [10]) and a US$100,000 reward offered by Johnson & Johnson remained unclaimed as of 2023. [11] [12] [13] Before the poisonings, Tylenol brands held around 35% of the US market for acetaminophen and in the immediate aftermath, fell to 8%.
A clinically severe interaction has been identified between aspirin and metamizole for patients who regularly take aspirin to manage vascular disease: this interaction occurs due to steric hindrance at the active aspirin binding site of COX-1 by metamizole; to manage this interaction, it is recommended to make a delay between the intake of each ...