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Asthma phenotyping and endotyping has emerged as a novel approach to asthma classification inspired by precision medicine which separates the clinical presentations of asthma, or asthma phenotypes, from their underlying causes, or asthma endotypes. The best-supported endotypic distinction is the type 2-high/type 2-low distinction.
Specialty. Pulmonology. Asthma is a common pulmonary condition defined by chronic inflammation of respiratory tubes, tightening of respiratory smooth muscle, and episodes of bronchoconstriction. [1] The Centers for Disease Control and Prevention estimate that 1 in 11 children and 1 in 12 adults have asthma in the United States of America. [1]
Asthma is a common condition and affects over 300 million people around the world. [3] Asthma causes recurring episodes of wheezing, breathlessness, chest tightness, and coughing, particularly at night or in the early morning. [4] Exercise-induced asthma is common in asthmatics, especially after participation in outdoor activities in cold weather.
Epidemiology of asthma. As of 2011, approximately 235 million people worldwide were affected by asthma, [2] and roughly 250,000 people die per year from asthma-related causes. [3] Low and middle income countries make up more than 80% of the mortality. [4] Prevalences vary between countries from 1% to 18%. [3]
Acute severe asthma. Silent chest, worsening symptoms despite use of medication. [1] Acute severe asthma, also known as status asthmaticus, is an acute exacerbation of asthma that does not respond to standard treatments of bronchodilators (inhalers) and corticosteroids. [2] Asthma is caused by multiple genes, some having protective effect, with ...
This first table gives a convenient overview of the general categories and broad causes. The leading cause is cardiovascular disease at 31.59% of all deaths. Rate of death by cause. Percent of all deaths. Category. Cause. Percent. Percent. I. Communicable, maternal, neonatal, and nutritional disorders.
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