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Bioconcentration. In aquatic toxicology, bioconcentration is the accumulation of a water-borne chemical substance in an organism exposed to the water. [ 1][ 2] There are several ways in which to measure and assess bioaccumulation and bioconcentration. These include: octanol-water partition coefficients (K OW ), bioconcentration factors (BCF ...
The Biopharmaceutics Classification System (BCS) is a system to differentiate drugs on the basis of their solubility and permeability. [1] This system restricts the prediction using the parameters solubility and intestinal permeability. The solubility classification is based on a United States Pharmacopoeia (USP) aperture.
Loratadine. Loratadine, sold under the brand name Claritin among others, is a medication used to treat allergies. [ 5] This includes allergic rhinitis (hay fever) and hives. [ 5] It is also available in drug combinations such as loratadine/pseudoephedrine, in which it is combined with pseudoephedrine, a nasal decongestant. [ 5]
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The pharmacokinetics of cetirizine have been found to increase linearly with dose across a range of 5 to 60 mg. [3] Its C max following a single dose has been found to be 257 ng/mL for 10 mg and 580 ng/mL for 20 mg. [2] Food has no effect on the bioavailability of cetirizine but has been found to delay the T max by 1.7 hours (i.e., to ...
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