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The typical dose is 1.5 mg/kg IV given three minutes prior to intubation. [34] Atropine may also be used as a premedication agent in pediatrics to prevent bradycardia caused by hypoxia, laryngoscopy, and succinylcholine. Atropine is a parasympathetic blocker. The common premedication dose for atropine is 0.01–0.02 mg/kg.
For symptomatic bradycardia, the usual dosage is 0.5 to 1 mg IV push; this may be repeated every 3 to 5 minutes, up to a total dose of 3 mg (maximum 0.04 mg/kg). [ 23 ] Atropine is also useful in treating second-degree heart block Mobitz type 1 (Wenckebach block) , and also third-degree heart block with a high Purkinje or AV-nodal escape rhythm .
IV dose 1-1.5mg/kg or 3 to 5 x ED 95. Paralysis occurs in one to two minutes. Clinical duration of action (time from drug administration to recovery of single twich to 25% of baseline) is 7-12 minutes. If IV access is unavailable, intramuscular administration 3-4mg/kg. Paralysis occurs at 4 minutes.
Atropine; Steroids. Dexamethasone (Decadron) is given in low dose at the onset of a general anesthetic as an effective antiemetic. It is also used in chemotherapy as a single drug as well as with other antiemetics such as 5-HT 3 receptor antagonists and NK1 receptor antagonist, but the specific mechanism of action is not fully understood. [16 ...
Diphenoxylate/atropine, also known as co-phenotrope and sold under the brand name Lomotil among others, is used to treat diarrhea. [ 2 ] [ 3 ] It is a fixed-dose combination of the medications diphenoxylate , as the hydrochloride, an antidiarrheal ; and atropine , as the sulfate, an anticholinergic . [ 1 ]
The use of atropine, lidocaine, and amiodarone have not been shown to improve survival from cardiac arrest. [116] [117] [81] Atropine is used for symptomatic bradycardia. It is given at a does of 1 mg (iv), and additional 1 mg (iv) doses can be given every 3–5 minutes for a total of 3 mg.
The Mark I NAAK (left) and its training kit (right) In the United States military, the Mark I NAAK, or MARK I Kit, ("Nerve Agent Antidote Kit") is a dual-chamber autoinjector: Two anti-nerve agent drugs—atropine sulfate and pralidoxime chloride—each in injectable form, constitute the kit.
In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose. [1] A loading dose is most useful for drugs that are eliminated from the body relatively slowly, i.e. have a long systemic half-life.