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  2. Hereditary sensory and autonomic neuropathy - Wikipedia

    en.wikipedia.org/wiki/Hereditary_sensory_and...

    The first sign of HSAN2 is usually numbness in the hands and feet. Soon after, affected individuals lose the ability to feel pain or sense hot and cold. People with HSAN2 often develop open sores (ulcers) on their hands and feet. Because affected individuals cannot feel the pain of these sores, they may not seek treatment right away.

  3. Hereditary sensory and autonomic neuropathy type I - Wikipedia

    en.wikipedia.org/wiki/Hereditary_sensory_and...

    The onset of the disease varies between the 2nd and 5th decade of life, [2] albeit congenital or childhood onset has occasionally been reported. [1] [9] With the progression of the disease, the affected individuals lose the ability to feel pain in their feet and legs. Minor injuries in the painless area can result in slow-healing wounds which ...

  4. Congenital insensitivity to pain with anhidrosis - Wikipedia

    en.wikipedia.org/wiki/Congenital_insensitivity...

    Those affected are unable to feel pain and temperature. [2] [3] The absence of pain experienced by people with CIPA puts them at high risk for accidental self-injury. Corneal ulceration occurs due to lack of protective impulses. [4] Joint and bone problems are common due to repeated injuries, and wounds heal poorly. [5]

  5. Congenital insensitivity to pain - Wikipedia

    en.wikipedia.org/wiki/Congenital_insensitivity...

    Because children and adults with the disorder cannot feel pain, they may not respond to problems, thus being at a higher risk of more severe diseases. Children with this condition often sustain oral cavity damage both in and around the oral cavity (such as having bitten off the tip of their tongue) or fractures to bones. [2]

  6. ‘My Low Back Pain Turned Out To Be A Rare Inflammatory ...

    www.aol.com/low-back-pain-turned-rare-120000344.html

    This drug results in rapid relief of symptoms and improved quality of life by reducing pain, stiffness, and disease progression, according to a 2024 study in Cureus. It was difficult for Steff to ...

  7. Peripheral mononeuropathy - Wikipedia

    en.wikipedia.org/wiki/Peripheral_mononeuropathy

    Another study by Jianren Mao et al. examined how “intrathecal treatment with dextrorphan or ketamine potently reduces pain-related behaviours in a rat model of peripheral mononeuropathy”. [11] Mao understands that “the experimental neuropathic pain syndrome seen in CCI rats is similar in many respects to the neuropathic pain syndrome seen ...

  8. Small fiber neuropathy - Wikipedia

    en.wikipedia.org/wiki/Small_fiber_peripheral...

    Small fiber neuropathy is a condition characterized by severe pain. Symptoms typically begin in the feet or hands but can start in other parts of the body. Some people initially experience a more generalized, whole-body pain. The pain is often described as stabbing or burning, or abnormal skin sensations such as tingling or itchiness. In some ...

  9. Leprosy - Wikipedia

    en.wikipedia.org/wiki/Leprosy

    Common symptoms present in the different types of leprosy include a runny nose; dry scalp; eye problems; skin lesions; muscle weakness; reddish skin; smooth, shiny, diffuse thickening of facial skin, ear, and hand; loss of sensation in fingers and toes; thickening of peripheral nerves; a flat nose from the destruction of nasal cartilages; and changes in phonation and other aspects of speech ...

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