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Prostaglandin E 2 (PGE 2), also known as dinoprostone, is a naturally occurring prostaglandin with oxytocic properties that is used as a medication. [2] [3] [4] Dinoprostone is used in labor induction, bleeding after delivery, termination of pregnancy, and in newborn babies to keep the ductus arteriosus open.
Aromatase excess syndrome (AES or AEXS) is a rarely diagnosed genetic and endocrine syndrome which is characterized by an overexpression of aromatase, the enzyme responsible for the biosynthesis of the estrogen sex hormones from the androgens, in turn resulting in excessive levels of circulating estrogens and, accordingly, symptoms of hyperestrogenism.
Larry and Cheryl's wedding gift for their friends, Ed and Melanie Loeb, is refused because it is over a year late. Larry interrupts sex with Cheryl to show her Jim's secret for removing stains. A household shop worker ( Laura Silverman ) annoys Larry by following him around her shop while he is browsing.
Some lesser known uses are as a means of high-dose estrogen therapy in the treatment of breast cancer in both women and men and in the treatment of prostate cancer in men. [22] [23] It has been used at a dosage of 2.5 mg three times per day (7.5 mg/day total) for prostate cancer. [24] [25]
A 2018 Cochrane review of studies on men over 60 with moderate to severe lower urinary tract symptoms analyzed the impacts of phosphodiesterase inhibitors (PDE) in comparison to other drugs. [90] These drugs may improve urinary symptoms slightly and reduce urinary bother but may also cause more side effects compared to placebo.
In the 1940s, the only available hormonal therapies for endometriosis were high-dose testosterone and high-dose estrogen therapy. [189] High-dose estrogen therapy with diethylstilbestrol for endometriosis was first reported by Karnaky in 1948 and was the main pharmacological treatment for the condition in the early 1950s. [190] [191] [192 ...
Curb Your Enthusiasm is an American television comedy of manners [2] [3] created by Larry David that premired on HBO with a hour-long special in October 17, 1999, with the rest of the episodes airing from October 15, 2000, to April 7, 2024.
A total of 177 episodes of House were broadcast over eight seasons, with the series finale airing on May 21, 2012. The show started on November 16, 2004, [14] and received a high viewing rating from the first episode to the last one.
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