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Clone directed therapy (anti-cancer therapy), immunomodulating medications (secondary approach), autologous stem cell transplantation, kidney transplantation, Monoclonal gammopathy of renal significance ( MGRS ) are a group of kidney disorders that present with kidney damage due to nephrotoxic monoclonal immunoglobulins (M proteins) secreted by ...
Glomerulonephrosis is a non-inflammatory disease of the kidney presenting primarily in the glomerulus (a glomerulopathy) as nephrotic syndrome.The nephron is the functional unit of the kidney and it contains the glomerulus, which acts as a filter for blood to retain proteins and blood lipids.
Glomerulosclerosis is the hardening of the glomeruli in the kidney. It is a general term to describe scarring of the kidneys' tiny blood vessels, the glomeruli, the functional units in the kidney that filter urea from the blood. Proteinuria (large amounts of protein in the urine) is one of the signs of glomerulosclerosis. Scarring disturbs the ...
Cancer: as happens in myeloma, the invasion of the glomeruli by cancerous cells disturbs their normal functioning. Genetic disorders : congenital nephrotic syndrome is a rare genetic disorder in which the protein nephrin , a component of the glomerular filtration barrier, is altered.
Glomerulonephritis (GN) is a term used to refer to several kidney diseases (usually affecting both kidneys). Many of the diseases are characterised by inflammation either of the glomeruli or of the small blood vessels in the kidneys, hence the name, [1] but not all diseases necessarily have an inflammatory component.
Focal segmental glomerulosclerosis (FSGS) is a histopathologic finding of scarring of glomeruli and damage to renal podocytes. [2] [3] This process damages the filtration function of the kidney, resulting in protein presence in the urine due to protein loss. [3]
Secondary diagnosis (i.e., ATN, interstitial nephritis, thrombotic microangiopathy) Ancillary studies, if done (i.e., IgG sub typing) Chronicity grade and score; The kidney biopsy is foundational to informing the diagnosis of mesangial proliferative glomerulonephritis, as it is a morphological pattern.
Monoclonal gammopathy of undetermined significance (MGUS) is a plasma cell dyscrasia in which plasma cells or other types of antibody-producing cells secrete a myeloma protein, i.e. an abnormal antibody, into the blood; this abnormal protein is usually found during standard laboratory blood or urine tests.