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Fexofenadine, sold under the brand name Allegra among others, [10] is an antihistamine pharmaceutical drug used in the treatment of allergy symptoms, such as hay fever and urticaria. [ 11 ] Therapeutically, fexofenadine is a selective peripheral H 1 blocker .
H 1 antagonists, also called H 1 blockers, are a class of medications that block the action of histamine at the H 1 receptor, helping to relieve allergic reactions.Agents where the main therapeutic effect is mediated by negative modulation of histamine receptors are termed antihistamines; other agents may have antihistaminergic action but are not true antihistamines.
There are four main types: H1, H2, H3, and H4. H1 receptors are linked to allergic responses, H2 to gastric acid regulation, H3 to neurotransmitter release modulation, and H4 to immune system function. There are four known histamine receptors: H 1 receptor H1 Receptors: These receptors are primarily located on smooth muscle cells, endothelial ...
It contains fexofenadine, as the hydrochloride, an antihistamine; and pseudoephedrine, as the hydrochloride, a nasal decongestant. [ 2 ] In 2021, it was the 279th most commonly prescribed medication in the United States, with more than 800,000 prescriptions.
H1-antihistamines are further split into three groups known as the first-generation, second-generation and third-generation antihistamines. Another type of antihistamines known as H2-antihistamines are used to treat gastrointestinal conditions caused by excessive stomach acid. [8] Mechanism
Rupatadine is a second generation, non-sedating, long-acting histamine antagonist with selective peripheral H 1 receptor antagonist activity. It further blocks the receptors of the platelet-activating factor (PAF) according to in vitro and in vivo studies.
Itching, sneezing, and inflammatory responses are suppressed by antihistamines that act on H1-receptors. [ 2 ] [ 8 ] In 2014, antihistamines such as desloratadine were found to be effective to complement standardized treatment of acne due to their anti-inflammatory properties and their ability to suppress sebum production.
Gravindex is an agglutination inhibition test performed on a urine sample to detect pregnancy. [1] It is based on double antigen antibody reaction. The test detects the prevention of agglutination of HCG -coated latex particles by HCG present in the urine of pregnant women.
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109 S High St #100, Columbus, OH · Directions · (614) 224-4261
"Your pet's prescription needs met at a price you can afford." - Patch