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For severe nerve pain, powerful opioid painkillers can help. Studies have found that for many types of nerve pain, they are as effective as anticonvulsants or antidepressants.
There are three options: Tricyclic antidepressants, such as amitriptyline (Elavil), doxepin (Sinequan), and nortriptyline (Pamelor). These drugs are prescribed for pain at doses lower than are effective for depression. Serotonin–norepinephrine reuptake inhibitors (SNRIs), such as duloxetine (Cymbalta) and venlafaxine (Effexor).
There are several treatment options for nerve pain, including antidepressants, anticonvulsants, opioids, and topicals. Learn about their uses and side effects.
Typical over-the-counter (OTC) pain relievers, like acetaminophen (Tylenol) and ibuprofen (Advil), aren’t very effective for nerve pain, and most people will need prescription-strength...
Some studies suggest that anti-inflammatory medications, such as diclofenac (Cataflam), might help people with sciatica. But there isn’t robust evidence to support most medications. For some people, combining amitriptyline and gabapentin (Neurontin) may help relieve sciatic nerve pain further.
Carfentanil: Carfentanil, a synthetic opioid, is a 100-fold stronger version of fentanyl. It has 5,000 times the potency of heroin and 10,000 times the potency of morphine. There has been an increase in the amount of carfentanil in narcotics, and this substance nearly invariably results in overdose and death. Fentanyl:
Some of the most commonly prescribed drugs for nerve pain are gabapentin, pregabalin, and duloxetine. However, these can lead to side effects such as drowsiness, nausea, dizziness, and...