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A popular example of drug–food interaction is the effect of grapefruit on the metabolism of drugs. Interactions may occur by simultaneous targeting of receptors, directly or indirectly. For example, both Zolpidem and alcohol affect GABA A receptors, and their simultaneous consumption results in the overstimulation of the receptor, which can ...
The specific interaction between drugs and their receptors is referred to as "drug action", and the widespread changes in physiological or psychological function is referred to as "drug effect". [2] These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.
[4] [3] Responses to a drug cue can be physiological (e.g., sweating, salivation, brain activity), behavioral (e.g., drug seeking), or symbolic expressive (e.g., craving). [3] The clinical utility of cue reactivity is based on the conceptualization that drug cues elicit craving which is a critical factor in the maintenance and relapse to drug use.
Cross-tolerance is a phenomenon that occurs when tolerance to the effects of a certain drug produces tolerance to another drug. It often happens between two drugs with similar functions or effects—for example, acting on the same cell receptor or affecting the transmission of certain neurotransmitters.
UpToDate's articles are anonymously peer-reviewed and it mandates the disclosure of conflicts of interest by the authors of its articles. In 2014, an article was published in the Journal of Medical Ethics which scrutinised six articles on UpToDate and DynaMed focusing on conditions where the best means of management is contested, or which are treated mostly by branded drugs.
An issue with this theory is that most addictive drugs cause an individual to build up a tolerance and the effects of the drug will decrease as an individual's tolerance increases. This requires individuals to use a higher dosage of the substance which in many causes can cause adverse side effects. [34] Dopamine is correlated with increased ...
This phenomenon can also be observed in adults who use the medication as a sleep aid. The prevalence of this paradoxical reaction is unknown, but research into the phenomenon suggests that it may be as a result of the medicine's interactions with the CYP2D6 enzyme, and that a metabolite of diphenhydramine may be to blame. [27]
Drug addiction, which belongs to the class of substance-related disorders, is a chronic and relapsing brain disorder that features drug seeking and drug abuse, despite their harmful effects. [31] This form of addiction changes brain circuitry such that the brain's reward system is compromised, [ 32 ] causing functional consequences for stress ...