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Purple glove syndrome (PGS) is a poorly understood skin disease in which the extremities become swollen, discoloured and painful. [1] PGS is potentially serious and may require amputation . PGS is most common among elderly patients and those receiving multiple large intravenous doses of the epilepsy drug phenytoin . [ 2 ]
Hypertrichosis, Stevens–Johnson syndrome, purple glove syndrome, rash, exfoliative dermatitis, itching, excessive hairiness, and coarsening of facial features can be seen in those taking phenytoin. Phenytoin therapy has been linked to the life-threatening skin reactions Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).
Side effects are similar to intravenous phenytoin and include hypotension, cardiac arrhythmias, CNS adverse events (nystagmus, dizziness, sedation/somnolence, ataxia and stupor), and local dermatological reactions. Purple glove syndrome probably occurs
The hypersensitivity syndrome is characterized by a rash that is initially rash that appears similar to measles (morbilliform). [2]: 118 The rash may also be one of the potentially lethal severe cutaneous adverse reactions, the DRESS syndrome, Stevens–Johnson syndrome, or toxic epidermal necrolysis.
Phenytoin, a CYP2C9 inducer, would increase its activity and the rate of warfarin breakdown, thereby reducing its efficacy. [25] Patients should avoid the co-administration of warfarin and phenytoin. In cases where both drugs must be used together, warfarin dosing may be titrated up to cope with the reduced efficacy. [26]
Pulmonary-renal syndrome; Purple glove syndrome; Purple urine bag syndrome; Q. Qazi–Markouizos syndrome; Quadrilateral space syndrome; Queen bee syndrome; R.
In March, a mother was horrified to find a pedophile symbol on a toy she bought for her daughter. Although the symbol was not intentionally placed on the toy by the company who manufactured the ...
Porphyria / p ɔːr ˈ f ɪr i ə / is a group of disorders in which substances called porphyrins build up in the body, adversely affecting the skin or nervous system. [1] The types that affect the nervous system are also known as acute porphyria, as symptoms are rapid in onset and short in duration. [1]