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The coiled-coil motif may also act as a spacer between two objects within a cell. The lengths of these molecular spacer coiled-coil domains are highly conserved. The purpose of these molecular spacers may be to separate protein domains, thus keeping them from interacting, or to separate vesicles within the cell to mediate vesicle transport.
330830 Ensembl ENSG00000159625 ENSMUSG00000031786 UniProt Q8IY82 Q6V3W6 RefSeq (mRNA) NM_001289162 NM_001289163 NM_032269 NM_001042715 RefSeq (protein) NP_001276091 NP_001276092 NP_115645 NP_001036180 Location (UCSC) Chr 16: 57.69 – 57.73 Mb Chr 8: 95.78 – 95.8 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Coiled-coil domain-containing protein 135, also known as CCDC135, is a ...
The protein contains three conserved domains including a coiled-coil domain between amino acids 27-74, a domain of unknown function between amino acids 72-260, and a serine-rich domain between amino acids 288-410. [10] It is believed that the 26-115 AA region is a SH3 domain. [11]
SMCO3 has a single domain, DUF4344 (aa15:221) which is currently uncharacterised. [16] C12orf60 also contains this domain. It contains a single transmembrane region (aa155-175) and has two coiled-coil regions (aa62-92, aa183-207). [17] The C-terminus of SMCO3 contains a KKXX-like motif suggesting endoplasmic reticulum localisation. [18]
Coiled coil domain containing protein 120 (CCDC120), also known as JM11 protein, is a protein that, in humans, is encoded by the CCDC120 gene. [5] The function of CCDC120 has not been formally identified but structural components, conservation, and interactions can be identified computationally.
Coiled-coil domain 47 (CCDC47) is a gene located on human chromosome 17, specifically locus 17q23.3 which encodes for the protein PAT complex subunit CCDC47. The protein itself contains coiled-coil domains , the SEEEED superfamily, a domain of unknown function (DUF1682) and a transmembrane domain.
This gene encodes a member of the hook-related protein family. Members of this family are characterized by an N-terminal potential microtubule binding domain, a central coiled-coiled and a C-terminal Hook-related domain. The encoded protein may be involved in linking organelles to microtubules. [provided by RefSeq, Oct 2009].
Coiled-coil domain containing 74A is a protein that in humans is encoded by the CCDC74A gene. [3] The protein is most highly expressed in the testis and may play a role in developmental pathways. [4] The gene has undergone duplication in the primate lineage within the last 9 million years, and its only true ortholog is found in Pan troglodytes.