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Research on the medical benefits of cannabis has been hindered by various federal regulations, including its Schedule I classification. [3] To conduct research on cannabis, approval must be obtained from the Food and Drug Administration, [4] and a license must be obtained from the Drug Enforcement Administration specific to Schedule I drugs. [5]
The analysis showed that people with cannabis use disorder were about 2.5 times more likely to develop an oral cancer; nearly five times more likely to develop oropharyngeal cancer, which is ...
Cannabis (/ ˈ k æ n ə b ɪ s /) [2] is a genus of flowering plants in the family Cannabaceae that is widely accepted as being indigenous to and originating from the continent of Asia. [3] [4] [5] However, the number of species is disputed, with as many as three species being recognized: Cannabis sativa, C. indica, and C. ruderalis.
[9] [10] Inside the transcriptomes of glandular trichomes in the cannabis plant, the pathway for cannabinoid production takes place. [9] Beginning with the formation of 3,5,7-trioxododecaneoyl-COA by the condensation reaction between hexanoyl-CoA and malonyl-CoA , catalyzed by type III polyketide synthase (PKS), the product is then used to form ...
Cannabis began to attract renewed interest as medicine in the 1970s and 1980s, in particular due to its use by cancer and AIDS patients who reported relief from the effects of chemotherapy and wasting syndrome. [91] In 1996, California became the first U.S. state to legalize medical cannabis in defiance of federal law. [92]
A 2012 review examining the relation of cancer and cannabis found little direct evidence that cannabinoids found in cannabis, including THC, are carcinogenic. Cannabinoids are not mutagenic according to the Ames test. However, cannabis smoke has been found to be carcinogenic in rodents and mutagenic in the Ames test.
Cannabis and Cannabinoid Research is a quarterly peer-reviewed academic journal published by Mary Ann Liebert since 2016 and "dedicated to the scientific, medical, and psychosocial exploration of clinical cannabis, cannabinoids, and the biochemical mechanisms of endocannabinoids".
Founded in 2002 by medical cannabis patient Steph Sherer, it has grown to over 100,000 members in 50 states. [122] Other groups include the National Organization for the Reform of Marijuana Laws, Marijuana Policy Project, and Drug Policy Alliance, although these focus more broadly on policy reform regarding both medical and non-medical use.