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In 2003, the IMG [21] agreed on diagnostic criteria for symptomatic myeloma, asymptomatic myeloma, and MGUS, ... Myeloma is the 17th-most common cancer in the UK ...
POEMS syndrome (also termed osteosclerotic myeloma, Crow–Fukase syndrome, Takatsuki disease, or PEP syndrome) is a rare paraneoplastic syndrome caused by a clone of aberrant plasma cells. The name POEMS is an acronym for some of the disease's major signs and symptoms ( p olyneuropathy , o rganomegaly , e ndocrinopathy , m yeloma protein , and ...
Criteria for diagnosis of Waldenström macroglobulinemia include: IgM monoclonal gammopathy that excludes chronic lymphocytic leukemia and mantle cell lymphoma . Evidence of anemia, constitutional symptoms, hyperviscosity, swollen lymph nodes , or enlargement of the liver and spleen that can be attributed to an underlying lymphoproliferative ...
Smouldering myeloma is a disease classified as intermediate in a spectrum of step-wise progressive diseases termed plasma cell dyscrasias.In this spectrum of diseases, a clone of plasma cells secreting monoclonal paraprotein (also termed myeloma protein or M protein) causes the relatively benign disease of monoclonal gammopathy of undetermined significance.
Monoclonal gammopathy of undetermined significance (MGUS) is a plasma cell dyscrasia in which plasma cells or other types of antibody-producing cells secrete a myeloma protein, i.e. an abnormal antibody, into the blood; this abnormal protein is usually found during standard laboratory blood or urine tests.
Light chain multiple myeloma is diagnosed in patients who have: a) the criteria for diagnosis of multiple myeloma except having a serum free light chain ratio outside the normal range of 0.26 to 1.65 without evidence of an intact immunoglobulin or free heavy chain; or b) an extreme free light chain ratio, i.e. outside the range of 0.02 to 100 ...
Blood Cancer UK, (formerly Bloodwise, Leukaemia & Lymphoma Research and the Leukaemia Research Fund) is a UK-based charity dedicated to funding research into all blood cancers including leukaemia, lymphoma and myeloma, as well as offering information and support to blood cancer patients.
Myeloproliferative neoplasms (MPNs) are a group of rare blood cancers in which excess red blood cells, white blood cells or platelets are produced in the bone marrow. Myelo refers to the bone marrow, proliferative describes the rapid growth of blood cells and neoplasm describes that growth as abnormal and uncontrolled.
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