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JWH-018 is a full agonist of both the CB 1 and CB 2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB 1 and 2.94 ± 2.65 nM at CB 2. [6] JWH-018 has an EC 50 of 102 nM for human CB 1 receptors, and 133 nM for human CB 2 receptors. [16]
JWH-018 [5] Naphthoylindole: 9 ± 5: 2.9 ± 2.6: CB 2 (3.1x) JWH-019: Naphthoylindole: 9.8 ± 2: 5.55 ± 2: CB 2 (1.77x) JWH-020: Naphthoylindole: 128 ± 17: 205 ± 20: CB 1 (1.6x) JWH-030: Naphthoylpyrrole: 87 ± 3: 320 ± 127: CB 1 (3.7x) JWH-031: Naphthoylpyrrole: 399 ± 109: JWH-032: Naphthoylpyrrole >10000 >10000 — JWH-033 ...
FUB-JWH-018 (also known as FUB-018) is a naphthoylindole-based synthetic cannabinoid, representing a molecular hybrid of JWH-018 and AB-FUBICA or ADB-FUBICA. [1] [2]
JWH-019 is an analgesic chemical from the naphthoylindole family that acts as a cannabinoid agonist at both the CB 1 and CB 2 receptors. It is the N -hexyl homolog of the more common synthetic cannabinoid compound JWH-018 .
NE-CHMIMO (CHM-018) is an indole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB 1 receptor and has been sold online as a designer drug. [ 1 ] [ 2 ] [ 3 ] NE-CHMIMO is the 1-cyclohexylmethyl (instead of 1-pentyl) analogue of the first-generation synthetic cannabinoid JWH-018 .
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JWH-081 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB 1 and CB 2 receptors. [3] With a K i of 1.2nM it is fairly selective for the CB 1 subtype, its affinity at this subtype is measured at approximately 10x the affinity at CB 2 (12.4nM). [ 4 ]
An assortment of several designer drugs. Designer drugs are structural or functional analogues of controlled substances that are designed to mimic the pharmacological effects of the parent drug while avoiding detection or classification as illegal.