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Isotretinoin, also known as 13-cis-retinoic acid and sold under the brand name Accutane among others, is a medication used to treat skin diseases like harlequin-type ichthyosis, and lamellar ichthyosis, and severe cystic acne or moderate acne that is unresponsive to antibiotics. [6]
Isotretinoin carries a high risk of causing severe birth defects if taken during pregnancy [5] (see Teratogenicity of isotretinoin) and the goals of the iPLEDGE REMS (risk evaluation and mitigation strategy) program are to prevent fetal exposure to isotretinoin and to inform prescribers, pharmacists, and patients about isotretinoin's serious ...
A chairperson and members of the Guidance Development Group were appointed, and posed review questions which enabled systematic evidence reviews to take place, thus delivering the guidance and subsequent recommendations. Service user and carer involvement took place throughout, as well as public consultation on the draft guidance.
An International Nonproprietary Name (INN) is an official generic and nonproprietary name given to a pharmaceutical substance or an active ingredient, [1] encompassing compounds, peptides and low-molecular-weight proteins (e.g., insulin, hormones, cytokines), as well as complex biological products, such as those used for gene therapy. [2]
Hanlon explained how their findings might influence prescribing: “Clinicians already balance a range of factors when deciding on the best treatment for an individual. This includes the person ...
Isotretinoin is a pharmaceutical derivative of retinoic acid (a metabolite of vitamin A). Its mechanism of action is believed to involve reduction in the amount of sebum produced by sebaceous glands on the skin's surface.
(Jury Trial) Vol. I - January 23, 2015 Pledger v. Janssen, et al. - PLEDGER, et al. -vs- JANSSEN, et al. - Page 65 1 report. 2 THE COURT: All right.So what is it 3 you're requesting?
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