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The Nikolsky sign is dislodgement of intact superficial epidermis by a shearing force, indicating a plane of cleavage in the skin epidermal-epidermal junctions (e.g., desmosomes). The histological picture involves thinner, weaker attachments of the skin lesion itself to the normal skin – resulting in easier dislodgement.
Diagnostic method > 30% of the skin involved, skin biopsy [3] Differential diagnosis: Chickenpox, staphylococcal epidermolysis, staphylococcal scalded skin syndrome, autoimmune bullous disease [3] Treatment: Hospitalization, stopping the cause, pain medication [3] Prognosis: Mortality 20–50% [2] [3] Frequency: 1–2 per million per year ...
The diagnosis is based on involvement of less than 10% of the skin. [2] It is known as TEN when more than 30% of the skin is involved and an intermediate form with 10 to 30% involvement. [3] A positive Nikolsky's sign is helpful in the diagnosis of SJS and TEN. [9] A skin biopsy is helpful, but not required, to establish a diagnosis of SJS and ...
SSSS is a clinical diagnosis. This is sometimes confirmed by isolation of S. aureus from blood, mucous membranes, or skin biopsy; however, these are often negative. Skin biopsy may show separation of the superficial layer of the epidermis (intraepidermal separation), differentiating SSSS from TEN, wherein the separation occurs at the dermo-epidermal junction (subepidermal separation).
CURB-65, also known as the CURB criteria, is a clinical prediction rule that has been validated for predicting mortality in community-acquired pneumonia [1] and infection of any site. [2] The CURB-65 is based on the earlier CURB score [ 3 ] and is recommended by the British Thoracic Society for the assessment of severity of pneumonia. [ 4 ]
Roughly 1 million adults in the U.S. seek hospital care due to pneumonia and 50,000 people die from it each year. "Pneumonia can become dangerous if it goes unrecognized and untreated.
[2] [3] It is seen along with Nikolsky's sign, both used to assess the severity of some blistering diseases such as pemphigus vulgaris and severe bullous drug reactions. [ 4 ] This sign is named for the Danish physician Gustav Asboe-Hansen (1917–1989), who first described it in 1960.
Pneumococcal pneumonia is a type of bacterial pneumonia that is caused by Streptococcus pneumoniae (pneumococcus). [1] It is the most common bacterial pneumonia found in adults, the most common type of community-acquired pneumonia, and one of the common types of pneumococcal infection. The estimated number of Americans with pneumococcal ...