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Dabrafenib is indicated as a single agent for the treatment of people with unresectable or metastatic melanoma with BRAF V600E mutation. [2] Dabrafenib is indicated, in combination with trametinib, for BRAF V600E-positive unresectable or metastatic melanoma, metastatic non-small cell lung cancer, metastatic anaplastic thyroid cancer, and unresectable or metastatic solid tumors.
When taken in combination with dabrafenib the most common side effects include fever, tiredness, nausea, chills, headache, diarrhea, vomiting, joint pain and rash. [5] In May 2013, trametinib was approved as a single-agent by the US Food and Drug Administration for the treatment of people with V600E mutated metastatic melanoma.
Maropitant (INN; [3] brand name: Cerenia, used as maropitant citrate , is a neurokinin-1 (NK 1) receptor antagonist developed by Zoetis specifically for the treatment of motion sickness and vomiting in dogs. It was approved by the FDA in 2007, for use in dogs [4] [5] and in 2012, for cats. [6]
(Reuters) -The U.S. Food and Drug Administration has approved Elanco Animal Health's skin disease treatment for dogs, the health regulator's website showed on Thursday, sending the company's ...
After good results in 2014, the combination was submitted to the European Medical Agency and the US Food and Drug Administration for marketing approval. [ 21 ] In January 2015, trial results compared vemurafenib with the combination of dabrafenib and trametinib for metastatic melanoma.
Most of the other contraindications are avoiding cases where a potential side effect exacerbates a pre-existing condition: for example, because oclacitinib can cause lumps or tumors, it should not be used in dogs with cancer or a history of it; [15] because it is an immune system suppressant, it should not be used in dogs with serious infections.
A number of common human foods and household ingestibles are toxic to dogs, including chocolate solids (theobromine poisoning), onion and garlic (thiosulfate, alliin or allyl propyl disulfide poisoning [109]), grapes and raisins (cause kidney failure in dogs), milk (some dogs are lactose intolerant and suffer diarrhea; goats' milk can be ...
This analgesic and anti-inflammatory drug is primarily used as a pain relief for mild to moderate inflammation related to osteoarthritis in dogs. Grapiprant has been approved by the FDA's Center for Veterinary Medicine and was categorized as a non- cyclooxygenase inhibiting non-steroidal anti-inflammatory drug (NSAID) in March 2016.