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The concept of "molecular glue" originated in the late 20th century, with immunosuppressants like cyclosporine A (CsA) and FK506 identified as pioneering examples. [2] CsA, discovered in 1971 during routine screening for antifungal antibiotics, exhibited immunosuppressive properties by inhibiting the peptidyl–prolyl isomerase activity of cyclophilin, ultimately preventing organ transplant ...
This is a common method used in households to remove a variety of stains. Depending on the stains composition, the stained material is left to soak in a container of warm or cool water and solvent. Such solvents can include laundry detergent, bleach, peroxide, vinegar, or a cleaning product with enzymes.
The distribution of the therapeutic enzyme in the body (biodistribution) after these IV infusions is not uniform. [10] The enzyme in less available to certain areas in the body, like the bones, lungs, brain. For this reason, many symptoms of lysosomal storage diseases remain untreated by ERT, especially neurological symptoms. [10]
A 98% biodegradable or other, [2] slightly moist absorbent cleaning compound may be spread evenly over carpet and brushed or scrubbed in. For small areas, a household hand brush can work such a compound into carpet pile; working like "tiny sponges", the attracted cleaning solution dissolves dirt, and dirt and grime is attracted/absorbed to the compound.
Since the enzyme in this process does not interact chemically with the polymer/ material of the support fibers/lattice, it remains protected from denaturation with time. [6] Basically, the enzyme is trapped in insoluble beads or microspheres, such as calcium alginate beads. However, these insoluble substances hinder the arrival of the substrate ...
These enzymes can also deamidate glutamine residues to glutamic acid residues in the presence of water [1] Gln-(C=O)NH 2 + H 2 O → Gln-COOH + NH 3. Transglutaminase isolated from Streptomyces mobaraensis-bacteria for example, is a calcium-independent enzyme. Mammalian transglutaminases among other transglutaminases require Ca 2+ ions as a ...
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