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  2. Janus kinase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Janus_kinase_inhibitor

    A Janus kinase inhibitor, also known as JAK inhibitor or jakinib, [1] is a type of immune modulating medication, which inhibits the activity of one or more of the Janus kinase family of enzymes (JAK1, JAK2, JAK3, TYK2), thereby interfering with the JAK-STAT signaling pathway in lymphocytes.

  3. Janus kinase 3 inhibitor - Wikipedia

    en.wikipedia.org/wiki/Janus_kinase_3_inhibitor

    Janus kinase 3 inhibitors, also called JAK3 inhibitors, are a new class of immunomodulatory agents that inhibit Janus kinase 3. They are used for the treatment of autoimmune diseases . The Janus kinases are a family of four nonreceptor tyrosine-protein kinases, JAK1 , JAK2 , JAK3 , and TYK2 .

  4. Category:Janus kinase inhibitors - Wikipedia

    en.wikipedia.org/wiki/Category:Janus_kinase...

    Janus kinase 3 inhibitor; Janus kinase inhibitor; M. Momelotinib; P. Peficitinib; Povorcitinib This page was last edited on 10 November 2023, at 16:05 (UTC). Text is ...

  5. Oclacitinib - Wikipedia

    en.wikipedia.org/wiki/Oclacitinib

    [1] [4] Chemically, it is a synthetic cyclohexylamino pyrrolopyrimidine janus kinase inhibitor that is relatively selective for JAK1. [5] It inhibits signal transduction when the JAK is activated and thus helps downregulate expression of inflammatory cytokines. [medical citation needed]

  6. Baricitinib - Wikipedia

    en.wikipedia.org/wiki/Baricitinib

    Baricitinib is a Janus kinase (JAK) inhibitor that reversibly inhibits Janus kinase 1 with a half maximal inhibitory concentration (IC 50) of 5.9 nM and Janus kinase 2 with an IC 50 of 5.7 nM. Tyrosine kinase 2, which belongs to the same enzyme family, is affected less (IC 50 = 53 nM), and Janus kinase 3 far less (IC 50 > 400 nM).

  7. Izencitinib - Wikipedia

    en.wikipedia.org/wiki/Izencitinib

    Izencitinib (TD-1473) is a drug which acts as a pan-Janus kinase inhibitor, binding with high affinity at all three subtypes JAK1, JAK2 and JAK3.It is taken orally and was developed to be gut selective with minimal absorption into the rest of the body, allowing targeting of inflammatory bowel disease but with reduced side effects compared to other similar drugs.

  8. Momelotinib - Wikipedia

    en.wikipedia.org/wiki/Momelotinib

    It is a Janus kinase inhibitor and it is taken by mouth. [2] The most common adverse reactions include dizziness, fatigue, bacterial infection, hemorrhage, thrombocytopenia, diarrhea, and nausea. [5] Momelotinib was approved for medical use in the United States in September 2023, [2] [5] [6] and in the European Union in January 2024. [3] [7]

  9. Fedratinib - Wikipedia

    en.wikipedia.org/wiki/Fedratinib

    It is a semi-selective inhibitor of Janus kinase 2 (JAK-2). [5] [6] It was approved by the FDA on 16 August 2019. [5] Myelofibrosis is a myeloid cancer associated with anemia, splenomegaly, and constitutional symptoms. Patients with myelofibrosis frequently harbor mutations which activate the JAK-STAT signaling pathway and which are sensitive ...

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