Search results
Results from the WOW.Com Content Network
The GM1 gangliosidoses, usually shortened to GM1, are gangliosidoses caused by mutation in the GLB1 gene resulting in a deficiency of beta-galactosidase.The deficiency causes abnormal storage of acidic lipid materials in cells of the central and peripheral nervous systems, but particularly in the nerve cells, resulting in progressive neurodegeneration.
Controlled phase II studies have indicated that GM1 can ease the symptoms of Parkinson's disease, presumably by countering degeneration of the substantia nigra, [6] and a similar methodology has been pursued to try and limit cellular damage from necrosis and apoptosis occurring after acute spinal cord injury.
Levels of anti-GM1 antibodies are especially elevated in patients with prodromal diarrhea. [7] Titers to GM1 in other diseases (rheumatoid arthritis, primary Sjögren's syndrome and systemic lupus erythematosus) was also elevated. [8] Additionally highly significant association was found with rheumatoid arthritis and peripheral neuropathies. [9]
Structure of GM1 ganglioside. A ganglioside is a molecule composed of a glycosphingolipid ... which results in a group of diseases called gangliosidosis.
This article about an endocrine, nutritional, or metabolic disease is a stub. You can help Wikipedia by expanding it.
GM1-gangliosidosis is a lysosomal storage disease that can be caused by a deficiency of β-galactosidase (GLB1). Some cases of Morquio syndrome B have been shown to be due to GLP1 mutations that cause patients to have abnormal elastic fibers. [9]
The scientists discovered that people who had smaller temporalis muscles had a 60 percent higher chance of developing Alzheimer’s disease or dementia. A smaller temporalis muscle size was also ...
Glycogen storage disease type I; Glycogen storage disease type II; Glycogen storage disease type III; Glycogen storage disease type V; Phosphofructokinase deficiency; GM1 gangliosidoses; GM2 gangliosidoses; GM2-gangliosidosis, AB variant; Goldmann–Favre syndrome; Gonadotropin-releasing hormone insensitivity; Griscelli syndrome