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The human genome contains about 500 protein kinase genes and they constitute about 2% of all human genes. [1] There are two main types of protein kinase. The great majority are serine/threonine kinases, which phosphorylate the hydroxyl groups of serines and threonines in their targets.
Mutations in kinases that lead to a loss-of-function or gain-of-function can cause cancer [8] and disease in humans, including certain types of leukemia and neuroblastomas, glioblastoma, [9] spinocerebellar ataxia (type 14), forms of agammaglobulinaemia, and many others. [10]
The protein kinase domain is a structurally conserved protein domain containing the catalytic function of protein kinases. [2] [3] [4] Protein kinases are a group of enzymes that move a phosphate group onto proteins, in a process called phosphorylation. This functions as an on/off switch for many cellular processes, including metabolism ...
Human Chk1 is located on chromosome 11 on the cytogenic band 11q22-23. Chk1 has a N-terminal kinase domain, a linker region, a regulatory SQ/TQ domain and a C-terminal domain. [9] Chk1 contains four Ser/Gln residues. [8] Chk 1 activation occurs primarily through the phosphorylation of the conserved sites, Ser-317, Ser-345 and less often at Ser-366.
Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the CDK2 gene. [ 5 ] [ 6 ] The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases .
Creatine kinase in the blood may be high in health and disease. Exercise increases the outflow of creatine kinase to the blood stream for up to a week, and this is the most common cause of high CK in blood. [16] Furthermore, high CK in the blood may be related to high intracellular CK such as in persons of African descent. [17]
695 12229 Ensembl ENSG00000010671 ENSMUSG00000031264 UniProt Q06187 P35991 RefSeq (mRNA) NM_001287345 NM_000061 NM_001287344 NM_013482 RefSeq (protein) NP_000052 NP_001274273 NP_001274274 NP_038510 Location (UCSC) Chr X: 101.35 – 101.39 Mb Chr X: 133.44 – 133.48 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Bruton's tyrosine kinase (abbreviated Btk or BTK), also known as ...
Tyrosine kinase function has been observed in the nuclear matrix. Lyn, the type of kinase that was the first to be discovered in the nuclear matrix, is part of Src family of tyrosine kinases, which can be contained in the nucleus of differentiating, calcium-provoked kertinocytes.