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Mechanism of self-amplifying mRNA (saRNA) used for antigen production. The ORF encoding the antigen can also be substituted with a protein for use in protein replacement therapy. This sequence encodes the protein of interest, used as an antigen in the case of vaccines or for protein replacement therapies. The gene of interest replaces the viral ...
Therapeutic use of saRNAs have been suggested. They have been tested in animal models to treat bladder tumors, [8] liver carcinogenesis, [9] [10] pancreatic cancer, [11] and erectile dysfunction. [12] In 2016, a phase I clinical trial involving advanced liver cancer patients [13] was launched for the saRNA drug MTL-CEBPA. It aimed to complete ...
Gritstone bio started in 2021 a phase 1 trial of an saRNA COVID-19 vaccine, used as a booster vaccine, with interim results published in 2023. [104] The vaccine is designed to target both the spike protein of the SARS‑CoV‑2 virus, and viral proteins that may be less prone to genetic variation, to provide greater protection against SARS ...
The preparation of ALC-0315 was first described in a patent application to lipid nanoparticles by Acuitas Therapeutics in 2017. [6]: 137 The final step is a reductive amination reaction in which 4-aminobutanol is condensed with a lipid aldehyde, using sodium triacetoxyborohydride as the reducing agent to convert the intermediate imines to the amine of the product.
Linda Sarna is an American nursing researcher and academic. She is dean, professor and Lulu Wolf Hassenplug Chair of the UCLA School of Nursing . Sarna was appointed the school's seventh dean Nov. 15, 2016, [ 1 ] after serving as acting dean (2014–2015) and interim dean (2015–2016).
The term "Sarna", derived from the Mundari language, means "sacred grove", referring to the sites where tribal religious practices take place, although the term for sacred grove varies among tribes; for instance, the Santals call it Jaher Era, Oraons call it Kurukh Kuti, Hos call it Desauli.
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A hookah lounge (also called a shisha bar or den, especially in Britain and parts of Canada, or a hookah bar) is an establishment where patrons share shisha (flavoured tobacco) from a communal hookah or from one placed at each table or a bar.
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