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Estrone, also known as estra-1,3,5(10)-trien-3-ol-17-one, is a naturally occurring estrane steroid with double bonds at the C1, C3, and C5 positions, a hydroxyl group at the C3 position, and a ketone group at the C17 position. The name estrone was derived from the chemical terms estrin (estra-1,3,5(10)-triene) and ketone.
Estrone is a naturally occurring and bioidentical estrogen, or an agonist of the estrogen receptor, the biological target of estrogens like endogenous estradiol. [5] It is a relatively weak estrogen, with much lower activity than estradiol. [5] However, estrone is converted in the body into estradiol, which provides most or all of its ...
During menopause, estrone is the predominant circulating estrogen and during pregnancy estriol is the predominant circulating estrogen in terms of serum levels. Given by subcutaneous injection in mice, estradiol is about 10-fold more potent than estrone and about 100-fold more potent than estriol. [ 14 ]
Esters of estrone that have been marketed include: [1] [2] Estrone acetate (Hovigal) Estrone sulfate (as the primary component of conjugated estrogens (Premarin)) Estropipate (Ogen, Ortho-Est) (a salt of estrone sulfate and piperazine) Estrone tetraacetylglucoside (Glucovex, Glycovex)
This is a list of steroidal estrogens or derivatives of estradiol, estrone, and estriol. Most esters of these estrogens are not included in this list; for esters, see here instead. Estradiol derivatives
Estrone sulfate (E1S) is an estrogen medication and naturally occurring steroid hormone. [1] It is used in menopausal hormone therapy among other indications. [ 1 ] [ 2 ] As the sodium salt (sodium estrone sulfate), it is the major estrogen component of conjugated estrogens (Premarin) and esterified estrogens (Estratab, Menest).
Esterified estrogens (EEs), sold under the brand names Estratab and Menest among others, is an estrogen medication which is used hormone therapy for menopausal symptoms and low sex hormone levels in women, to treat breast cancer in both women and men, and to treat prostate cancer in men.
Estrogenic substances were also distinct from pure crystalline preparations such as estrone, estradiol, estriol, estradiol benzoate, and estradiol dipropionate. [1] The medication should additionally be distinguished from estrogen ovarian extracts, which had little activity and were considered to be essentially inactive.