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Secretion of hCG can occur as soon as 6 days following ovulation and on average 8–10 days following ovulation; this is the earliest hCG can be detected in a blood sample. [7] [5] [8] The hCG concentration in blood is higher than in urine. Therefore, a blood test can be positive while the urine test is still negative. [9] [10]
The term "multiple-marker screening test" is sometimes used instead. [1] [2] This term can encompass the "double test" and "quadruple test" (described below). The Triple screen measures serum levels of AFP, estriol, and beta-hCG, with a 70% sensitivity and 5% false-positive rate.
Human chorionic gonadotropin is a glycoprotein composed of 237 amino acids with a molecular mass of 36.7 kDa, approximately 14.5kDa αhCG and 22.2kDa βhCG. [4]It is heterodimeric, with an α (alpha) subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and a β (beta) subunit that is unique to hCG.
The triple test measures serum levels of AFP, estriol, and beta-hCG, with a 70% sensitivity and 5% false-positive rate. It is complemented in some regions of the United States, as the Quad test (adding inhibin A to the panel, resulting in an 81% sensitivity and 5% false-positive rate for detecting Down syndrome when taken at 15–18 weeks of ...
1082 n/a Ensembl ENSG00000104827 n/a UniProt P0DN86 n/a RefSeq (mRNA) NM_000737 n/a RefSeq (protein) NP_000728.1 NP_149032.1 NP_149133.1 NP_149439.1 NP_149032 NP_149439 n/a Location (UCSC) Chr 19: 49.02 – 49.02 Mb n/a PubMed search n/a Wikidata View/Edit Human Choriogonadotropin subunit beta (CG-beta) also known as chorionic gonadotrophin chain beta is a protein that in humans is encoded by ...
The presence of hCG in a woman's body indicates that a fertilized egg has implanted in the uterus and the placenta has started to form. 10 days after fertilization, significant hCG can be detected from woman's blood sample. [6] The levels of hCG in the body increase rapidly in the first few weeks of pregnancy, doubling every 48–72 hours. [7]
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The hormone hCG is produced at high levels by a pregnant woman's placenta, which is why it is used to depict positive results for these kinds of tests. At the Test Site, the trapped hCG is sandwiched in between a fixed antibody with a dye substrate, resulting in the first line of the pregnancy test appearing.
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