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Methotrexate was originally developed and continues to be used for chemotherapy, either alone or in combination with other agents.It is effective for the treatment of several cancers, including solid tumours of breast, head and neck, lung, bladder, as well as acute lymphocytic leukemias, non-Hodgkin's lymphoma, osteosarcoma, and choriocarcinoma and other trophoblastic neoplasms.
The drug methotrexate (bottom) is an antimetabolite that interferes with the metabolism of folic acid (top) An antimetabolite is a chemical that inhibits the use of a metabolite , which is another chemical that is part of normal metabolism . [ 1 ]
5.1 Mechanism of action. 5.2 Pharmacokinetics. 6 Chemistry. 7 History. 8 Society and culture. ... methotrexate, or psoralen and ultraviolet-A light. ...
Methotrexate is commonly associated with dose-related toxic effects involving the bone marrow and gastrointestinal tract. [12] Folic acid may be given weekly to help diminish the frequency of side-effects. [12] Methotrexate is also associated with acute and chronic liver damage. Other adverse effects include: [12] Life-threatening Interstitial ...
The cytotoxic antibiotics are a varied group of drugs that have various mechanisms of action. The common theme that they share in their chemotherapy indication is that they interrupt cell division . The most important subgroup is the anthracyclines and the bleomycins ; other prominent examples include mitomycin C and actinomycin .
Methotrexate is an injected drug used to treat a wide variety of cancers ranging from acute lymphoblastic leukemia in child. The U.S. Food and Drug Administration said on Friday it is seeking new ...
Methotrexate is an injected drug used to treat cancers ranging from acute lymphoblastic leukemia in children, breast cancer, lung cancer, bone cancers and certain types of head and neck cancers ...
President-elect Donald Trump’s Surgeon General nominee caused a gun accident when she was 13-years-old that left her dad shot dead.