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If you have untreated gout for a long time, something called tophi can develop. Tophi is when uric acid crystals around the joints form larger, hard deposits. It can lead to pain, soft tissue ...
About 10% of people with hyperuricemia develop gout at some point in their lifetimes. [19] The risk, however, varies depending on the degree of hyperuricemia. When levels are between 415 and 530 μmol/L (7 and 8.9 mg/dL), the risk is 0.5% per year, while in those with a level greater than 535 μmol/L (9 mg/dL), the risk is 4.5% per year.
“While men develop gout more often than women, women are more likely to develop gout after menopause,” says Iroku-Malize. This is due to the drop in estrogen in perimenopause.
Without treatment, tophi may develop on average about ten years after the onset of gout, although their first appearance can range from three to forty-two years. The development of gouty tophi can also limit joint function and cause bone destruction, leading to noticeable disabilities, especially when gout cannot successfully be treated. [2]
Gout can occur where serum uric acid levels are as low as 6 mg per 100 mL (357 μmol/L), but an individual can have serum values as high as 9.6 mg per 100 mL (565 μmol/L) and not have gout. [ 18 ] In humans, purines are metabolized into uric acid, which is then excreted in the urine.
However, there are things you can do to help protect your joint health while promoting overall well-being. Follow the tips below to prevent arthritis: Eat a healthy, balanced diet .
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