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Microcrystalline cellulose (MCC) is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. [1] The most common form is used in vitamin supplements or tablets.
The moisture sorption properties of pharmaceutical materials such as excipients, drug formulations and packaging films are recognized as critical factors in determining their storage, stability, processing and application performance. [1] [2] Further, vapor sorption experiments can be used to study hydrate [3] and solvate [4] formation.
[14] [15] This material was later referred to as microcrystalline cellulose (MCC) and commercialised under the name Avicel by FMC Corporation. [16] Nanocellulose gel (probably MFC of NFC) Microfibrillated cellulose (MFC) was discovered later, in the 1980s, by Turbak, Snyder and Sandberg at the ITT Rayonier labs in Shelton, Washington.
Cellulose is the raw material in the manufacture of nitrocellulose (cellulose nitrate) which is used in smokeless gunpowder. Pharmaceuticals: Cellulose derivatives, such as microcrystalline cellulose (MCC), have the advantages of retaining water, being a stabilizer and thickening agent, and in reinforcement of drug tablets. [73]
A wide variety of binders may be used: some common ones are lactose, dibasic calcium phosphate, sucrose, corn (maize) starch, microcrystalline cellulose, povidone polyvinylpyrrolidone and modified cellulose (for example, hydroxypropyl methylcellulose and hydroxyethylcellulose).
An excipient is a substance formulated alongside the active ingredient of a medication.They may be used to enhance the active ingredient’s therapeutic properties; to facilitate drug absorption; to reduce viscosity; to enhance solubility; to improve long-term stabilization (preventing denaturation and aggregation during the expected shelf life); or to add bulk to solid formulations that have ...
Molecular Pharmaceutics is a peer-reviewed scientific journal covering research on the molecular mechanistic understanding of drug delivery and drug delivery systems, including physical and pharmaceutical chemistry, biochemistry and biophysics, molecular and cellular biology, and polymer and materials science.
Pharmaceutical Research is an official journal of the American Association of Pharmaceutical Scientists and covers research spanning the entire spectrum of drug discovery, development, evaluation, and regulatory approval.