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Aging theories based on evolvability; Aging theories based on group selection; Antagonistic pleiotropy hypothesis; C. Cross-linking theory of aging; D. Disposable ...
The two theories; non-adaptive, and adaptive, are used to explain the evolution of senescence, which is the decline in reproduction with age. [8] The non-adaptive theory assumes that the evolutionary deterioration of human age occurs as a result of accumulation of deleterious mutations in the germline. [8]
Disengagement theory was formulated by Cumming and Henry in 1961 in the book Growing Old and was the first theory of aging that social scientists developed. [5] Thus, the theory has historical significance in gerontology. Since then, it has faced strong criticism since the theory was proposed as innate, universal, and unidirectional. [6]
Biogerontology should not be confused with geriatrics, which is a field of medicine that studies the treatment of existing disease in aging people, rather than the treatment of aging itself. There are numerous theories of aging, and no one theory has been entirely accepted.
The mutation accumulation theory of aging was first proposed by Peter Medawar in 1952 as an evolutionary explanation for biological aging and the associated decline in fitness that accompanies it. [1] Medawar used the term 'senescence' to refer to this process.
The activity theory and the disengagement theory were the two major theories that outlined successful aging in the early 1960s. [4] The theory was developed by Robert J. Havighurst in 1961. [ 1 ] In 1964, Bernice Neugarten asserted that satisfaction in old age depended on active maintenance of personal relationships and endeavors.
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. The hallmarks of aging are the types of biochemical changes that occur in all organisms that experience biological aging and lead to a progressive loss of physiological integrity, impaired function and, eventually, death.
In biogerontology, the disposable soma theory of aging states that organisms age due to an evolutionary trade-off between growth, reproduction, and DNA repair maintenance. [1] Formulated by British biologist Thomas Kirkwood , the disposable soma theory explains that an organism only has a limited amount of resources that it can allocate to its ...