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Excitotoxicity can occur from substances produced within the body (endogenous excitotoxins).Glutamate is a prime example of an excitotoxin in the brain, and it is also the major excitatory neurotransmitter in the central nervous system of mammals. [14]
A controversy surrounding the safety of MSG began on 4 April 1968, when Robert Ho Man Kwok wrote a letter to the New England Journal of Medicine, coining the term "Chinese restaurant syndrome". [57] [58] In his letter, Kwok suggested several possible causes before he nominated MSG for his symptoms.
Monosodium glutamate (MSG) might not cause headaches or other symptoms of so-called Chinese restaurant syndrome in the general population. Many studies that found a biological effect were done on rats or other lab animals, or used unusually large doses of MSG, and these can't necessarily be extrapolated to humans.
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In general, it is recommended that a combination of psychological and physiological treatments should be used to treat the disorder. [ 12 ] Other drugs which may be helpful in the treatment of this condition include dopamine agonists , oxytocin , phosphodiesterase type 5 inhibitors , and alpha-2 receptor blockers like yohimbine .
These factors have been more extensively explored in men than in women. Physical etiologies such as neurological and cardiovascular illnesses have been directly implicated in both premature and retarded ejaculation as well as in erectile disorder, [6] but the contribution of physiological factors to female sexual dysfunction is not so clear ...
The controversy surrounding the safety of MSG started with the publication of Dr. Robert Ho Man Kwok's correspondence letter titled "Chinese-Restaurant Syndrome" in the New England Journal of Medicine on 4 April 1968. [22] [23] In his letter, Kwok suggested several possible causes for symptoms that he experienced before he nominated MSG.
Some women have experienced such multiple orgasms quite spontaneously. While young women may become sexually aroused quite easily, and reach orgasm relatively quickly with the right stimulation in the right circumstances, there are physical and psychological changes to women's sexual arousal and responses as they age.