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In a recent analysis (Susac et al., 2003), MRI images from 27 patients fulfilling the diagnostic criteria of Susac's syndrome were reviewed. Multifocal supratentorial lesions were present in all patients. Most lesions were small (3 to 7 mm), though some were larger than 7 mm. All 27 patients had corpus callosum lesions. These all had a punched ...
The supratentorial region contains the cerebrum, while the infratentorial region contains the cerebellum. Although the Roman era anatomist Galen commented upon it, the functional significance of this neuroanatomical division was first described using ‘modern’ terminology by John Hughlings Jackson , founding editor of the medical journal Brain .
The patient may become paralyzed on the same side as the lesion causing the pressure, or damage to parts of the brain caused by herniation may cause paralysis on the side opposite the lesion. [11] Damage to the midbrain , which contains the reticular activating network which regulates consciousness , will result in coma . [ 11 ]
Lesions in the area of cerebellopontine angle cause signs and symptoms secondary to compression of nearby cranial nerves, including cranial nerve V (trigeminal), cranial nerve VII (facial), and cranial nerve VIII (vestibulocochlear). The most common cerebellopontine angle (CPA) tumor is a vestibular schwannoma affecting cranial nerve VIII (80% ...
The free border of the tentorium is U-shaped; it forms an aperture - the tentorial notch (tentorial incisure) - which gives passage to the midbrain.The free border of each side extends anteriorly beyond the medial end of the superior petrosal sinus (i.e. the apex of the petrous part of the temporal bone [citation needed]) to overlap the attached margin, thenceforth forming a ridge of dura ...
The distribution of the lesions could be linked to the clinical evolution [25] Post-mortem autopsies reveal that gray matter demyelination occurs in the motor cortex, cingulate gyrus, cerebellum, thalamus and spinal cord. [26] Cortical lesions have been observed specially in people with SPMS but they also appear in RRMS and clinically isolated ...
Symptoms patients present at time of diagnosis include irritable mood, visual difficulties, lethargy, and ataxia. [2] The circumference of the patient's head might also become enlarged and they might be subject to seizures, especially if they have less than one year of life. [2] Several analysis can be used to determine the presence of the disease.
Of the patients with neurological damage, the majority had a lesion in the supratentorial left hemisphere. Lesions primarily affected the: premotor cortex, motor cortex, basal ganglia or Broca's area. Lesions are also seen in the cerebellum, which projects to the previous areas. Right hemisphere damage rarely causes FAS.