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Pyrrole is an extremely weak base for an amine, with a conjugate acid pK a of −3.8. The most thermodynamically stable pyrrolium cation (C 4 H 6 N +) is formed by protonation at the 2 position. Substitution of pyrrole with alkyl substituents provides a more basic molecule—for example, tetramethylpyrrole has a conjugate acid pK a of +3.7.
19.56 (pK a of conjugate acid in acetonitrile) [3] Magnetic susceptibility (χ)-54.8·10 −6 cm 3 /mol ... Pyrrole (aromatic with two double bonds) Pyrroline (one ...
Pyrazole is a weak base, with pK b 11.5 (pK a of the conjugate acid 2.49 at 25 °C). [3] According to X-ray crystallography , the compound is planar. The two C-N distances are similar, both near 1.33 Å [ 4 ]
1-Pyrroline-5-carboxylic acid (systematic name 3,4-dihydro-2H-pyrrole-2-carboxylic acid [2]) is a cyclic imino acid. Its conjugate base and anion is 1-pyrroline-5-carboxylate (P5C). In solution, P5C is in spontaneous equilibrium with glutamate-5-semialdhyde (GSA).
A conjugate acid, within the Brønsted–Lowry acid–base theory, is a chemical compound formed when an acid gives a proton (H +) to a base—in other words, it is a base with a hydrogen ion added to it, as it loses a hydrogen ion in the reverse reaction.
A library of substituted pyrrole analogs can be quickly produced by using continuous flow chemistry (reaction times of around 8 min.). [10] The advantage of using this method, as opposed to the in-flask synthesis, is that this one does not require the work-up and purification of several intermediates, and could therefore lead to a higher ...
Pyrrole-2-carboxylic acid is an organic compound with the formula HNC 4 H 3 CO 2 H. It is one of two monocarboxylic acids of pyrrole. It is a white solid. It arises in nature by dehydrogenation of the amino acid proline. [1] It also arises by carboxylation of pyrrole. [2] The ethyl ester of this acid is readily prepared from pyrrole. [3]
Dissolving Knorr's pyrrole in concentrated sulfuric acid, and then pouring the resulting solution into water will hydrolyze the 4-ester group selectively. The 5-methyl group can be variously oxidized to chloromethyl, aldehyde, or carboxylic acid functionality by the use of stoichiometric sulfuryl chloride in glacial acetic acid. [7]