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  2. Lamina propria - Wikipedia

    en.wikipedia.org/wiki/Lamina_propria

    Progression of epithelial cancer often relies on deep and regional lymph node invasion. [12] The lamina propria, being one of the barriers to the submucosa, is an area where epithelial cancer invasion is of significance since lymphatic invasion is an independent predictor of lymph node metastasis, especially in gastric cancer. [13]

  3. Gut-associated lymphoid tissue - Wikipedia

    en.wikipedia.org/wiki/Gut-associated_lymphoid_tissue

    The gut-associated lymphoid tissue lies throughout the intestine, covering an area of approximately 260–300 m 2. [5] In order to increase the surface area for absorption, the intestinal mucosa is made up of finger-like projections (), covered by a monolayer of epithelial cells, which separates the GALT from the lumen intestine and its contents.

  4. Mucosal immunology - Wikipedia

    en.wikipedia.org/wiki/Mucosal_immunology

    These Tregs further travel to the lamina propria of villi through lymphatic vessels. There, Tregs produce IL-10 and IL-35, which affects other immune cells in the lamina propria toward a tolerogenic state. [17] However, damging the homeostasis of the intestinal barrier leads to inflammation.

  5. Gastrointestinal wall - Wikipedia

    en.wikipedia.org/wiki/Gastrointestinal_wall

    The lamina propria, a layer of connective tissue within the mucosa. The muscularis mucosae, a thin layer of smooth muscle. The epithelium, the most exposed part of the mucosa, is a glandular epithelium with many goblet cells. Goblet cells secrete mucus, which lubricates the passage of food along and protects the intestinal wall from digestive ...

  6. Histopathology of colorectal adenocarcinoma - Wikipedia

    en.wikipedia.org/wiki/Histopathology_of...

    Colorectal adenocarcinoma is distinguished from a colorectal adenoma (mainly tubular and ⁄or villous adenomas) mainly by invasion through the muscularis mucosae. [10] In carcinoma in situ (Tis), cancer cells invade into the lamina propria, and may involve but not penetrating the muscularis mucosae. This can be classified as an adenoma with ...

  7. Mucous membrane - Wikipedia

    en.wikipedia.org/wiki/Mucous_membrane

    The mucosa is composed of one or more layers of epithelial cells that secrete mucus, and an underlying lamina propria of loose connective tissue. [1] The type of cells and type of mucus secreted vary from organ to organ and each can differ along a given tract. [2] [3]

  8. Microfold cell - Wikipedia

    en.wikipedia.org/wiki/Microfold_cell

    These cells are known to initiate mucosal immunity responses on the apical membrane of the M cells and allow for transport of microbes and particles across the epithelial cell layer from the gut lumen to the lamina propria where interactions with immune cells can take place. [1]

  9. Colon cancer staging - Wikipedia

    en.wikipedia.org/wiki/Colon_cancer_staging

    Tis: Carcinoma in situ; Cancer cells are found only in the epithelium or lamina propria; T1: Growth into the submucosa; T2: Growth into the muscularis propria; T3: Growth through the muscularis propria and into the subserosa, or into tissues surrounding the colon or rectum (but not the visceral peritoneum or surrounding organs).